Dr. Sanjay Surase, Dr. Snehal Chavhan, Dr. Kalpana Deshpande, Dr. Mayur Sonawane


Background: Abnormal uterine bleeding is a major gynaecological problem accounting for 33% of Gynaec outpatients. The aim of this study was
to evaluate the various histopathological patterns in the endometrial biopsy of patients presenting with abnormal uterinebleeding and to determine
the specific pathology in the different age groups.
Methods: This was a prospective study done on120 patients with abnormal uterine bleeding were included in the study. Histopathological
examination of the endometrial biopsy was done and the various histopathological patterns identified and classified.
Results: The age of patients ranged from 40-45 years.The most frequent findings were proliferative endometrium in 38.3 % and also disordered
proliferative (15%), secretory endometrium(20.8%), and endometrial hyperplasia (13.3%) are different lesion.
Conclusions: Endometrial curettings and biopsy is an important diagnostic procedure for assessing all cases of abnormal uterine bleeding and to
plan for successful management.


Endometrial Hyperplasia, secretory, Menorrhagia

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Tavassoli FA, Devilee P editors, Tumours of the uterine corpus. In: WHO classifications of tumours. Pathology and genetics of tumours of the breast and female genital organs. Lyon France: IARC press. 2003:221-32.

Munro MG. Abnormal uterine bleeding in the reproductive years: Pathogenesis and clinical investigations. J Am Assoc Gynecol laparos. 1999;6:393-416.

Mencoglia L, Perino A, Hamou J. Hysteroscopy in perimenopausal and post-menopausal women with abnormal uterine bleeding. J Reprod Med. 1987;32:577-82.

Brand A, Dubuc-Lissoir J, Ehlen TG, Plante M. Diagnosis of endometrial cancer in women with abnormal vaginal bleeding. J Soc Obstet Gynecol Can. 2000;22:102-4.

Stovall TG, Ling FW, Morgan PL. A prospective randomized comparison of the Pipelle endometrial sampling device with the Novak curette. Am J Obstet Gynecol. 1991;165(5,1):1287-90.

Clark TJ, Mann CH, Shah N, Khan KS, Song F, Gupta JK. Accuracy of outpatient endometrial biopsy in the diagnosis of endometrial cancer: A Systematic Quantitative review. BJOG. 2002;109:313-21.

Dijkhuizen FP, Mol BW, Brolman HA, Heintz AP. The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma andhyperplasia: a meta-analysis. Cancer. 2000;8:1765- 72

Rosai J. Female reproductive system-uterus-corpus. In: Rosai and Ackerman’s surgical pathology. 9th edition; Mosby: an imprint of Elsevier, Missouri, 2005;1579-615.

Dangal G. A study of endometrium of patients with abnormal uterine bleeding at Chitwan valley. Kathmandu University. Med J. 2003;1:110-2.

Khan R, Sherwani R, Rana S, Hakim S, Jairajpuri ZS. Clinico-Pathological Patterns in Women with Dysfunctional Uterine Bleeding. Iran J Pathol. 2016;11(1):20-6.

Muzaffar M, Akhtar KAK, Yasmin S, Rahman M, Iqbal W, Khan MA. Menstrual irregularities with excessive blood loss: A Clinico-Pathological Correlation. J Pak Med Assoc. 2005;55:486-9.

Yusuf NW, Nadeem R, Yusuf AW, Rahman R. Dysfunctional Uterine Bleeding. A retrospective clinicopathological study over 2 years. Pak J Obstet Gynecol.1996;9:27-30.

Doraiswami S, Johnson T, Rao S, Rajkumar A, Vijayaraghavan J, Panicker V. Study of endometrial pathology in Abnormal Uterine bleeding. J Obstet Gynecol India. 2011;61(4):426-30.

Damle RP, Dravid NV, Suryawanshi KH, Gadre AS, Bagale P S, Ahire N. Clinicopathological spectrum of endometrial changes in peri-menopausal and post- menopausal Abnormal Utrine Bleeding: a 2 year study. J Clin Diagn Res. 2013;7(12):2774-6.

Bhatta S, Sinha AK. Histopathological study ofendometrium in abnormal uterine bleeding. J Pathol Nepal. 2012;2:297-300.

Khare A, Bansal R, Sharma S, Elhence P, Makkar N,

Tyagi Y. Morphological spectrum of Endometrium in patients presenting with Dysfunctional Uterine Bleeding. People’s Journal of Scientific Research. 2012;5(2)13-6.

Khan S, Hameed S, Umber A. Histopathological pattern of Endometrium on Diagnostic D and C in patients with Abnormal Uterine Bleeding. Annals. 2011;17(2):166-70.

Sheetal GP, Bhute SB, Inamdar SA, Acharya NS, Shrivastava DS. Role of diagnostic hysteroscopy in abnormal uterine bleeding and its histopathological correlation. J Endosc Surg. 2009;1(2):98-104.

Fakhar S, Saeed G, Khan AH, Alam AY. Validity of pipelle endometrial sampling in patients with abnormal uterine bleeding. Ann Saudi Med. 2008;28(3):188-91.

Bhosle A, Fonseca M. Evaluation and Histopathological correlation of Abnormal Uterine Bleeding in Perimenopausal women. Bombay Hospital Journal. 2010;52(1):69-72.

Jetley S, Rana S, Jairajpuri ZS. Morphological spectrum of endometrial pathology in middle-agedwomen with atypical uterine bleeding: A study of 219 cases. J Midlife Health. 2013;4(4):216-20.

Chary N, Fathima A, Rani J. Endometrial histopathological changes associated with Dysfunctional Uterine Bleeding. Asian Pac J Health

Sci. 2016;3(2):106-9.

Michail G, Karahaliou A, Skiadopoulos S, Kalogeropoulou C, Terzis G, Boniatis I et al. Texture analysis of perimenopausal and post-menopausal endometrial tissue in gray scale transvaginal ultrasonography. Br J Radiol. 2007;80:609-16.

Abdulla LS, Bondagji NS. Histopathological pattern of Endometrial Sampling performed for Abnormal Uterine Bleeding. Bahrain Medical Bulletin. 2011;33(4):1-6.

Baral R, Pudasaini S. Histopathological pattern of endometrial samples in abnormal uterine bleeding. J Pathol Nepal. 2011;1:13-6.

Moghal N. Diagnostic value of endometrial curettage in abnormal uterine bleeding- a histopathological study. J Pak Med Assoc. 1997;47:295-9.

Valle RF. Hysteroscopic evaluation of patients with abnormal uterine bleeding. Surg Gynecol Obst. 1981;153:521-6.

Jyotsana, Manhas K, Sharma S. Role of hysteroscopy and laparoscopy in evaluation of abnormal uterine bleeding. JK Sci. 2004;6:1.

Jong PD, Doel F, Falconer A. Outpatient diagnostic hysteroscopy. Br J Obstet Gynecol. 1990;97:2.


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