ASSOCIATION OF SERUM MAGNESIUM LEVEL WITH DIABETES MELLITUS
Abstract
Magnesium is an essential ion for human health, as it is involved in virtually every mechanism in the cell. Multiple factors in diabetic patients lead to hypomagnesemia. Hypomagnesemia in turn leading to deterioration of glycemic control and increased incidence of microvascular complication of diabetes mellitus. Thus, this study is undertaken to evaluate the relationship of serum magnesium with glycemic control and microvascular complications of type 2 DM.
Aims and objectives:
To estimate serum magnesium levels in type 2 Diabetes mellitus. To study the association of hypomagnesemia with glycemic control and microvascular complications of type 2 diabetes mellitus.
Settings and Design:
Case-control study
Methods and Material:
70 type 2 diabetes mellitus patients’ serum magnesium was assessed and was grouped into cases and controls according to the serum magnesium. Cases have Mg of 1.6mg/dl or less and controls with Mg of more than 1.6mg/dl. Glycemic control was compared among both the groups.
Statistical analysis used:
Data were entered in MS-Excel and analyzed in SPSS V22. Chi-square test, t-test were applied to find significance. Karl Pearson correlation or spearman correlation was applied depends on nature of the data. P<0.05 was considered as statistically significant.
Results:
There was no significant difference in mean duration of diabetes among both groups. Mean FBS was significantly (p= 0.03) high among the cases (221.33mg/dl) compared to controls (175.31mg/dl). Mean glycosylated hemoglobin, an important marker of glycemic control is 9.99g% and 8.46 g% among cases and controls respectively. (p = 0.002).
Conclusion:
Hypomagnesemic diabetic patients have poor glycemic control when compared with patients with normal magnesium levels.
Keywords
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Sanders GT, Huijgen HJ, Sanders R. Magnesium in disease: a review with special emphasis on the serum ionized magnesium. Clinical chemistry and laboratory medicine. 1999 18;37(11-12):1011-33.
Elamin A, Tuvemo T. Magnesium and insulin-dependent diabetes mellitus. Diabetes research and clinical practice. 1990 1;10(3):203-9.
Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A. Magnesium: an update on physiological, clinical and analytical aspects. Clinica chimica acta. 2000 1;294(1- 2):1-26.
Sales CH, Pedrosa LD. Magnesium and diabetes mellitus: their relation. Clinical nutrition. 2006 1;25(4):554-62.
Pham PC, Pham PM, Pham PA, Pham SV, Pham HV, Miller JM, Yanagawa N, Pham PT. Lower serum magnesium levels are associated with more rapid decline of renal function in patients with diabetes mellitus type 2. Clinical nephrology. 2005 1;63(6).
Dzúrik R, Stefíková K, Spustová V, Fetkovská N. The role of magnesium deficiency in insulin resistance: an in vitro study. Journal of hypertension. 1991 1;9:S314.
Gommers LM, Hoenderop JG, Bindels RJ, de Baaij JH. Hypomagnesemia in type 2 diabetes: a vicious circle?. Diabetes. 2016 1;65(1):3-13
Wahid A, Verma GC, Meena CP, Pathan AR. Study of serum magnesium level in patients with type 2 diabetes mellitus and it’s correlation with glycosylated hemoglobin and diabetic complications. International Journal of Advances in Medicine. 2017 23;4(2):311-6.
Dasgupta A, Sarma D, Saikia UK. Hypomagnesemia in type 2 diabetes mellitus. Indian journal of endocrinology and metabolism. 2012;16(6):1000-06.
Kundu D, Osta M, Mandal T, Bandyopadhyay U, Ray D, Gautam D: Serum magnesium levels in patients with diabetic retinopathy. J Nat Sci Biol Med. 2013; 4(1):113-6.
Khubchandani AS, Sanghani H. Study of serum magnesium and HbA1C in diabetic patients along with changes in their lipid profiles. Indian Journal of Clinical Practice. 2013;23(11):717-9.
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