A STUDY OF LIPID PROFILE AND ITS RELATIONSHIP WITH BLOOD GLUCOSE LEVEL IN METABOLIC SYNDROME

Dr. Tarang Shah, Dr. Abhi Doshi, Dr. Nilay Suthar, Dr. Dipak Solanki, Dr. Ajay Rathod

Abstract


Background: Metabolic syndrome (MetS) and its associated factors such as dyslipidemia and hyperglycemia are associated with increased risk of
cardiovascular disease (CVD).
Aims and Objective: To assess lipid profile and its relation with blood glucose levels in patients with MetS.
Materials and Methods: This cross-sectional study included 320 patients with MetS. Anthropometry, lipid profile, blood glucose, and presence of
MetS (NECP APT3 ) were determined.
RESULT :High LDL-C was the most common lipid abnormality observed in these patients. High LDL-C (>100 mg/dl) that is including
suboptimal and high level were observed in 75.93% patients. Whereas high total triglyceride, high cholesterol, and low HDL level were found in
59.68% , 47.18% , 41.87% respectively. On intergroup comparison of NFG, IFG, and T2DM among patients with MetS, no statistically significant
difference in lipid levels was observed.
Conclusion: we conclude that dyslipidemia is a common feature of MetS, and a large number of patients had more than one individual lipid
abnormality. Most common dyslipidemia was high LDL-C and least was low HDL. Pattern of the dyslipidemia was similar in all three groups based
on blood glucose levels.


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References


Alberti KG, Zimmet P, Shaw J. Metabolic syndrome—a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 2006;23(5):469–80.

Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK. Cardiovascular risk factors in confirmed pre-diabetic individuals: does the clock for coronary heart disease start ticking before the onset of clinical diabetes? JAMA. 1990;263:2893–8.

Chahil TJ, Ginsberg HN. Diabetic dyslipidemia. Endocrinol Metab Clin North Am. 2006;35:491–510.

Jeppesen J, Hein HO, Suadicani P, Gyntelberg F. Relation of high TG-low HDL cholesterol and LDL cholesterol to the incidence of ischemic heart disease. An 8-year follow-up in

the Copenhagen Male Study. Arterioscler Thromb Vasc Biol. 1997;17:1114–20.

Assmann G, Schulte H. Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience). Prospective Cardiovascular Munster study. Am J Cardiol. 1992;70:733–7.

Kawamoto R, Tabara Y, Kohara K, Miki T, Kusunoki T, Takayama S, et al. Relationships between lipid profiles and metabolic syndrome, insulin resistance and serum high molecular adiponectin in Japanese community-dwelling adults. Lipids Health Dis. 2011;10:79.

Goodarzi MT, Mohammadian M, Borzouei S, Hassanzadeh T. Association between plasma cholesteryl ester transfer protein activity and lipid profiles in metabolic syndrome in an Iranian population. Int Res J Biol Sci. 2014;3(4):87–90.

Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chem. 1972;18:499–502.

Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640–5.

National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. Circulation. 2002;106:3143.

Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part

: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539–53.

Bal SS, Khurana D, Sharma A, Lal V, Bhansali A, Prabhakar S. Association of metabolic syndrome with carotid atherosclerosis in the young North Indian population. Diabetes Metab Syndr. 2011;5(3):153–7.

Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444:881–7.

Maheux P, Azhar S, Kern PA, Chen YD, Reuven GM. Relationship between insulin-mediated glucose disposal and regulation of plasma and adipose tissue lipoprotein lipase. Diabetologia. 1997;40:850–8.

Adiels M, Olofsson SO, Taskinen MR, Boren J. Overproduction of very low-density lipoproteins is the hallmark of the dsylipidemia in the metabolic syndrome. Arterioscler Thromb Vasc Biol. 2008;28:1225–36.

Assmann G, Gotto AM Jr. HDL Cholesterol and protective factors in atherosclerosis. Circulation. 2004;109:III-8–III-14.

Pandya H, Lakhani JD, Dadhania J, Trivedi A. The prevalence and pattern of dyslipidemia among type 2 diabetic patients at rural based hospital in Gujarat, India. Indian J Clin Pract. 2012;22(12):36–44.

U.K. Prospective Diabetes Study 27: Plasma lipids and lipoproteins at diagnosis of NIDDM by age and sex. Diabetes Care. 1997;20(11):1683–7.

Cowie CC, Howard BV, Harris MI. Serum lipoproteins in African Americans and whites with non-insulin dependent diabetes in the US population. Circulation. 1994;90(3):1185–93.

Ginsberg HN. Insulin resistance and cardiovascular disease. J Clin Invest. 2000;106:453–8.

Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009; 120:1640.


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