URIC ACID : AN INFLAMATORY MARKER IN PREECLAMPSIA

Dr Priyank Udagani, Dr Vibha. C, H. L. Vishwanath

Abstract


The pregnancy is the state of carrying a developing embryo or fetus within female body1. Preeclampsia affects 3-5% of pregnancies. Placental ischemia and
inflammation occur due to impaired trophoblastic invasion in uterine spiral artery. Preeclampsia is an idiopathic multisystem disorder that typically starts
after the 20th week of pregnancy; high blood pressure is a main contributing factor. Ten million women develop preeclampsia each year around the world. In
hypertensive pregnancy however, there is incomplete trophoblastic invasion upto decidual vessels, but not upto myometrial vessels. Because of this,
myometrial spiral arteriolar lumen remains narrow which impairs blood flow to produce placental hypoxia.
Aim and Objectives: Aim of the study is to study wheather Uric Acid is an inflammatory marker of Preclampsia.
Results : 30 women in preeclamptic compared with 30 normal pregnant with similar age and period of gestation . The mean SBP of the cases and controls
are 157.7 mm of Hg and 113.6 mm of Hg with significant p value < 0.0001. The mean DBPin cases and controls is 101.4 mm of Hg and 77.47 mm og Hg with
significant p< 0.0001. The mean serum uric acid in cases and controls are 6.41 mg/dl and 4.33 mg/dl respectively With p < 0.0001.


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References


Maternal physiology. In Cunningham F, Lenevo K, Bloom S, Hauth J, Rouse D, Spong C (Edts). Williams Obsterrics, 23rd ed. USA: The McGraw-Hill companies. 2010; 107-131.

Ob-Gyns Issue Task Force Report on Hypertension in Pregnancy: Preeclampsia Diagnosis No Longer Requires Presence of Proteinuria

Kuklina EV, et al. Hypertensive Disorders and Severe Obstetric Morbidity in the United States. Obstet Gynecol 2009; 113:1299-306.

Kamath S. Hypertension in pregnancy. [Editorial]. JAPI. 2006; 54: 269-270.

Bansal S. Hypertension in pregnancy. In: Desai P, Malhotra N, Shah D (Edts). Principles & practice of Obstetrics & Gynecology for post-graduates. 3rd ed. New Delhi: Jaypee Borthers. 2008; 100-107.

Powers RW, Bodnar LM, Ness RB. Uric acid concentration in early pregnancy among preeclamptic women with gestational hyperuricemia at delivery. Am J Obstet Gynecol 2006;194:160.

Many A, Hubel CA, Roberts JM. Hyperuricemia and xanthine oxidase in preeclampsia , revisited. Am J Obstet Gynecol. 1996; 174: 288-91.

Slemmons J, Bogert L. The uric acid content of maternal and fetal blood. J bio Chem 1917;32: 63-9.

Bainbridge SA, Roberts JM. Uric acid as a pathogenic factor in preeclampsia . Placenta 2008: 29: 67-72.

Thangaratinam S, Ismail KM, Sharp S, Coomarasamy A, Khan KS. Tests in prediction of preeclampsia severity review group. Accuracy of serum uric acid in predicting complications of preeclampsia; a systemic review. BJOG 2006: 113 : 369-78.

Johnson RJ, Kang DH, Feig D, Kiilvighn S, Kannellis J, Wantanabe S et al. Is there a

pathogenic role of uric acid in hypertension and cardiovascular and renal disease ?

Hypertension . 2003 ; 41: 1183-90. [Pubmed: 12707287].

Amir Taefl, Ashraf Sadat Jamal, Human Delavari MD. The role of serum uric acid in preeclampsia . Journal Of Family and Reproductive Health 2008: 2(3): 159-162.

Triveni K. Prathap T. Uric Acid As An Important Biomarker In Hypertensive Disorders In Pregnancy . International Journal Of Reproduction , Contraception , Obstetrics and Gynaecology. 2016:5(12): 4382.

Krishna TS, Krishnamma M, Rajeswari DR, Rao V, Naidu JN et al,. Alterrations of serum uric acid concentrations in preeclampsia. Int J Applied Bio Pharmaceutical Tech . 2015;6(2):165-7.


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