A COMPARISON OF ORAL PREGABALIN AND ORAL CLONIDINE FOR THE ATTENUATION OF HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION AND THE TIME FOR RESCUE ANALGESIC IN THYROID SURGERIES

Dr. Linette Serah Thomas, Dr. Vishma K

Abstract


Background and Aims: Our study had been designed to compare the effect of oral pregabalin and clonidine on cardiovascular response from laryngoscopy and endotracheal intubation and also to find the time for rescue analgesia in patients undergoing thyroidectomies.

Materials and Methods: 78 adult patients scheduled for thyroid surgeries were divided randomly into two groups. Group C received clonidine 200 μg and Group P received pregabalin 150 mg as oral premedication. The heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded serially. Time for rescue analgesia in the postoperative period was also noted.

Results: Clonidine showed significantly better attenuation of stress response to laryngoscopy and intubation than pregabalin. The mean time for rescue analgesia after thyroidectomy was higher in pregabalin group.

Conclusion: Attenuation of hemodynamic response of laryngoscopy and intubation was better with clonidine whereas pregabalin was a better analgesic.


Keywords


Pregabalin, Clonidne, Laryngoscopy, Thyroidectomy

Full Text:

PDF

References


Shribman AJ, Smith G, Achola KJ. Cardiovascular and catecholamine responses to laryngoscopy with and without tracheal intubation. Br J Anaesth 1987;59:295–9.

Kovac AL. Controlling the hemodynamic response to laryngoscopy and endotracheal intubation. J Clin Anesth 1996;8:63–79.

da Silva Neto WV, Azevedo GS, Coelho FO, Netto EM, Ladeia AM. Evaluation of hemodynamic variations during anesthetic induction in treated hypertensive patients. Rev Bras Anestesiol 2008;58:330–41.

Singh S, Arora K. Effect of oral clonidine premedication on perioperative haemodynamic response and postoperative analgesic requirement for patients undergoing laparoscopic cholecystectomy. Indian J Anaesth 2011;55:26–30.

Taylor CP, Angelotti T, Fauman E. Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res 2007;73:137–50.

Joshi GP, Ogunnaike BO. Consequences of inadequate postoperative pain relief and chronic persistent postoperative pain. Anesthesiol Clin North Am 2005;23:21–36.

Channaiah VB, Kurek NS, Moses R, Chandra SB. Attenuation of hemodynamic response to laryngoscopy and endotracheal intubation with pre induction IV fentanyl versus combination of IV fentanyl and sub lingual nitroglycerin spray Med Arch. 2014;68:339-44.

Gupta K, Sharma D, Gupta PK. Oral premedication with pregabalin or clonidine for hemodynamic stability during laryngoscopy and laparoscopic cholecystectomy: A comparative evaluation. Saudi J Anaesth 2011;5:179-84.

Montazeri K, Kashefi P, Honarmand A, Safavi M, Hirmanpour A. Attenuation of the pressor response to direct laryngoscopy and tracheal intubation: oral clonidine vs. oral gabapentin premedication. J Res Med Sci 2011; 16:377–386.

Sundar AS, Kodali R, Sulaiman S, et al. The effects of preemptive pregabalin on attenuation of stress response to endotracheal intubation and opioid‑sparing effect in patients undergoing off‑pump coronary artery bypass grafting. Ann Card Anaesth 2012; 15:18–25.

Rathore P, Saini V, Ahmed F, Chatterjee R, Rathore M. A comparative study of oral clonidine versus oral pregabalin on hemodynamic responses to laryngoscopy and endotracheal intubation under general anaestesia. International Journal of Medical and Biomedical Studies 2019;3:217-22.

Bindu M, Kumar AA, Kesavan M, Suresh V. Effect of preoperative pregabalin on postoperative pain relief in thyroidectomy patients: A prospective observational study Anesth Essays Res 2015;9:161–6.

Hu J, Huang D, Li M, Wu C, Zhang J. Effects of a single dose of preoperative pregabalin and gabapentin for acute postoperative pain: a network meta-analysis of randomized controlled trials. J Pain Res 2018;11:2633-43.

Singh S, Arora K. Effect of oral clonidine premedication on perioperative haemodynamic response and post-operative analgesic requirement for patients undergoing laparoscopic cholecystectomy. Indian Journal of Anaesthesia 2011;55:26-30.


Refbacks

  • There are currently no refbacks.