Dr. B. Balaji Naik


Introduction: Shingles is a localised distribution, affects individual nerve and its particular dermatome; develops in persons who have been exposed to chicken pox in the past. Various therapeutic modalities are available for this, but only few of them are effective. The present study is aim is to know the clinicoepidemiological study and complications of shingles.

Materials and Methods: Patient details, dermatological lesions presentation, systemic examination findings were all collected in a pre-structured proforma. Patients were advised to undergo routine blood and urine examination, random blood sugar, HIV and specific investigations if required. Patients were followed up every week and observed for complications.

Results: Out of 116, 94 (81.08%) were immunocompetent and 22 (18.9%) immunocompromised patients. Out of 116 cases, 44 (37.9%) were males and remaining 72 (62.06%) were females. Most common clinical presentation was dermatological pain (74.1%) followed by burning sensation (68.9%), rash (45.6%). Post Herpetic Neuralgia (28.4%) is the most common complication observed followed by Sensory loss (24.1%), Ocular complications (19.8%) and secondary infection.

Conclusion: Complications were observed most commonly among Immunocompromised patients, so clinician should treat these patients promptly like treatment of HZV infection and its associated pain, post herpetic neuralgia prevention, supporting treatment until neurological pain resolves .


Shingles, Immunocompromised, Immunocompetent persons

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Bloch K, Johnson J. Varicella Zoster virus transmission in the vaccine era : unmasking the role of Herpes Zoster. J Infect Dis. 2012;205:1331-1333.

Robert W Johnson, Marie Jose Alvarez – Pasquin, Marc Bijl, Elisabetta Franco, Jacques Gaillat, Joao G Clara, Marc Labetoulle, Jean-Pierre Michel, Luigi Naldi, Luis S Sanmarti, and Thomas Weinke. Herpes zoster epidemiology, management, and disease and economic burden in Europe: a multidisciplinary perspective. TherAdv Vaccines. 2015 Jul;3(4):109-120.

Bricout H, Haugh M, Olatunde O, Gil Prieto R. Herpes zoster-associated mortality in Europe: a systematic review. BMC Public Health 2015;15: 466.

Ono F, Yasumoto S, Furumura M, Hamada T, Ishii N, Gyotoku T, et al. Comparison between famciclovir and valacyclovir for acute pain in adult japaneseimmunocompetent patients with herpes zoster. J Dermatol 2012;39:902-8.

Homsy J, Katabira E, Kabatesi D, Mubiru F. Evaluating herbal medicine for the management of Herpes Zoster in Human Immunodeficiency Virus infected patients in Kampala, Uganda. J Altern Complement Med. 1999 Dec;5(6):553-65.

Dworkin RH, Johnson RW, Breuer J, Gnann JW et al. Recommendations for the management of Herpes Zoster. Clin Infect Dis. 2007 Jan. 44 Suppl 1:S 1-6.

Strauss SE. Overview; the biology of varicella – zoster virus infection. Ann Neurol. 1994;35 (Suppl): S4-8.

Bowsher D. Pathophysiology of post herpetic neuralgia : towards a rational treatment. Neurology. 1995;45:S56-7.

Pergan SA, Forsberg CW, Bocck MJ, Maynard C, Limaye AP, Ward A et al. Herpes zoster incidence in a multicentre cohort of solid organ transplant recipients. Transpl Infect Dis. 2011;13(1):615-623.

Yawn BP, Wollan PC, Kurland MJ, St sauver JL, Saddier P. Herpes Zoster recurrences more frequent than previously reported. Mayo Clin Proc. 2011;86(2):88-93.

Buchbinder SP, Katz MH, Hessol NA, Liu JY, Omalley PM, Underwood R et al. Herpes Zoster and Human Immunodeficiency Virus Infection. J Infect Dis. 1992;166(5):1153-6.

Toyama N, Shiraki K. society of the Miyazaki prefecture Dermatologist. Epidemiology of herpes zoster and its relationship to varicella in Japan: a 10 year survey of 48,388 herpes zoster cases in Miryazaki prefecture. J Med Virol.2009;81:2053-2058.

Donahue JG, Choo PW, Manson JE, Platt R. The Incidence of HZ. Arch Intern Med. 1995;155:1605-9.

Kim YJ, Lee CN, Lim CY, Jeon WS, Park YM. Population-based study of the epidemiology of herpes zoster in korea. J Korean Med Sci 2014;29:1706-10.

Di Legami V, Gianino MM, CiofidegliAtti M, Massari M, Migliardi A, Tomba GS, et al. Epidemiology and costs of herpes zoster: Background data to estimate the impact of vaccination. Vaccine 2007;25:7598-604.

Seth John Stankus, Michael Dlugopolski, Deborah Packer. Management of Herpes Zoster (Shingles) and Post herpetic neuralgia. Am Fam Physician. 2000 Apr 15;61(8):2437-2444.

Gauthier A, Breuer J, Carrington D, Martin M, Remy V. Epidemiology and cost of herpes zoster and post-herpetic neuralgia in the United Kingdom. Epidemiol Infect. 2009;137(1):38–47.

Insinga RP, Itzler RF, Pellissier JM, Saddier P, Nikas AA. The incidence of herpes zoster in a United States administrative database. J Gen Intern Med. 2005;20(8):748–53.

Ultsch B, Siedler A, Rieck T, Reinhold T, Krause G, Wichmann O. Herpes zoster in Germany: quantifying the burden of disease. BMC Infect Dis. 2011;11:173.

Chen SY, Suaya JA, Li Q, Galindo CM, Misurski D, Burstin S, et al. Incidence of herpes zoster in patients with altered immune function. Infection 2014;42:325-34

Hata A, Kuniyoshi M, Ohkusa Y. Risk of herpes zoster in patients with underlying diseases: A retrospective hospital-based cohort study. Infection 2011;39:537-44.

Yang YW, Chen YH, Lin HW. Risk of herpes zoster among patients with psychiatric diseases: A population-based study. J EurAcadDermatolVenereol 2011;25:447-53.

Blein C, Gavazzi G, Paccalin M, Baptiste C, Berrut G, Vainchotock a. Burden of Herpes Zoster : the direct and comorbidity costs of HZ events in hospitalized patients over 50 years in France/ BMC Infect Dis. 2015 aug 19; 15(1): 350.

Johnson R, Rice A. Clinical practice: postherpetic neuralgia. N Engl J Med 2014;371: 1526–1533.

Hope- Simpson RE: The nature of herpes zoster: a long term study and a new hypothesis. Proc R Soc Med 58: 9, 1965.

Gauthier A, Breuer J, Carrington D, Martin M, Rémy V. Epidemiology and cost of herpes zoster and post-herpetic neuralgia in the united kingdom. Epidemiol Infect 2009;137:38-47.

Gialloreti LE, Merito M, Pezzotti P, Naldi L, Gatti A, Beillat M, et al. Epidemiology and economic burden of herpes zoster and post-herpetic neuralgia in italy: A retrospective, population-based study. BMC Infect Dis 2010;10:230.

Tran KD, Falcone MM, Choi DS, Goldhardt R, Karp CL, Davis JL, et al. Epidemiology of herpes zoster ophthalmicus: Recurrence and chronicity. Ophthalmology 2016;123:1469-75.

Oxman M, Levin M, Johnson G, Schmader K, Straus S, Gelb L et al. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med 2005;352: 2271–2284.


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