SYNTHESIS, SPECTRAL STUDY, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF COPPER (II) COMPLEX OF CHALCONE OF 5-NITROFURFURAL

S. N. Ipper, G. K. Kakade

Abstract


A metal complex of Cu(II) has been synthesized with newly prepared biologically active ligand. This ligand was prepared by the Claisen-Schmidt
condensation method of 2,6-dihydroxy acetophenone and 5-Nitrofurfural. The structure of the complex has been proposed by the analytical data,
conductivity measurement, magnetic moment, electronic absorption spectrum, thermal studies and XRD analysis. Analytical data conrmed 1:2
stoichiometry and the magnetic moment, TG-DTA suggests that Cu(II) complex has octahedral geometry. Presence of coordinated water
molecules in Cu(II) complex is conrmed by TG-DTA studies. The conductivity data show that the complex was non electrolyte. Antimicrobial
activities of complex with selected bacterial strain and fungal strain carried out and the results have been compared with commercial standards. The
metal complex exhibit impressible potent biocidal activity than ligand.


Keywords


TG-DTA, XRD study, Antimicrobial activities, Physico-chemical property, Magnetic susceptibility and Conductivity

Full Text:

PDF

References


S.V.Kostanecki, and Tambar, J.Chem.Ber., 32:1921(1899).

N.V.Damme,V.Zaliskyy,A.J.Lough,M.T. Lemaire, Polyhedron, 89, (2015) 155-159.

V. N. Patange ,B. R. Arbad, Synthesis, spectral, thermal and biological studies of transition metal complexes of 4-hydroxy-3-[3-(4-hydroxyphenyl)-acryloyl]-6-methyl-2H-pyran-2-one, J. Serb. Chem. Soc. 76 (9) (2011) 1237–1246.

A. J. Deshmukh, R. M. Patil, R. S. Lokhande and D. H. Ner, Synthesis, characterization and antimicrobial activity of copper (II) complexes of some 2-hydroxy-4, 5-dimethyl substituted chalcones, International Journal of Advanced Research and Review, 3(1), 2017, 27-31.

Hong jin, Yucong Geng, Zhiyi Y.C, Ke Jao, Jaiping Hou. (2009). Pesticide Biochemistry and Physiology, 93133-137.

Habib, S.I., Kulkarni, P.A.(2015). Synthesis and antimicrobial activity of chalcone derivatives of Ni(II) and Co(II) complexes-an in vitro evaluation, ICAIJ,10(4), [152-156].

S.N. Ipper, N.K. Raut and G.K. Kakde, Physico-chemical properties of furan chalcone. Indian Journal of Applied Research. 2017; 7(6):683-684.

Sirsat, S.B., Halikar, N.K. Pund, M.M. and Vartale, S.P. (April/June2012). Synthesis and biological screening of some novel hetero-aryl-chalcone and their Complexes.Research Journal of Pharmaceutical Biological and Chemical Sciences. Vol.3 issue 2, 240-248.

Hong-Yun, Z., Dong-Li, C., Pei-Kun, C., De-Ji, C., Guang-Xia, C., Hong-Quan, Z., (1992). Polyhedron, 11, 2313.

Reddy, Vidyavati. Patil, N. and Angadi S.D. (2008 July). Synthesis, characterization and antimicrobial activity of Cu(II), Co(II) and Ni(II) complexes with O,N and S doner ligands; E-Journal of Chemistry Vol. 5, No.3, 577-583.

A. L. Barry, Procedure and therotical consideration for testing antimicrobial agents in agar media, 5th Edition, William Wilkiins Baltimore (1991).

S. I. Habib, S. G. Konda, M. A . Basser, P. A. Kulkarni,Asian J. Research Chem., Oct-Dec, 2( 4), ( 2009).

Sengupta, S. K., Pandey, B. K., Shrivastava, B. K., and Sharma, V. K.,(1998). Transition Metal Chem., 23, 4, 349-353.


Refbacks

  • There are currently no refbacks.