Dr. Abiram. P, Dr. Cordelia Babitha, Dr. Adikrishnan. S, Dr. Murugan. S


Bushke  Lowenstein  Tumour  or  Giant  Condyloma  Acuminata  is  a  seldom  seen  manifestation  of  Human  Papilloma  virus  types  6  and  11.  The incidence  is  about  0.5%  in  the  general  population.  Although  the  malignant  risk  is  low,  it  warrants  timely  removal  and  management.  The treatment  varies  from  topical  Imiquimod  to  Cryotherapy  to  Wide  local excision.  Prompt  and  early  treatment  needs  to  be  instituted  to  avoid bothersome  effects  and  to hamper  the  malignant  progression [55-60%]. In view  of  high  recurrence  rates [65-70%],  regular surveillance is mandatory. We  are  presenting  this  case  to  reiterate  the  rarity  and  low  malignant  risk, in  contrary  to  the  ominous  presentation,  and  to  highlight  the  importance of  timely  identification  and  management.


Buschke Lowenstein Tumour, Giant Condyloma Acuminata, HPV 6,11, Low malignant risk

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Lévy A, Lebbe C. Buschke-Löwenstein tumour: diagnosis and treatment. Ann Urol (Paris) 2006;40:175-178

Steffen C. The men behind the eponym - Abraham Buschke and Ludwig Lowenstein: giant condyloma (Buschke-Loewenstein) Am J Dermatopathol. 2006;28:526–536

Longacre TA, Kong CS, Welton ML. Diagnostic problems in anal pathology. Adv Anat Pathol. 2008;15:263–278

Loewenstein L.W. Carcinoma-like condylomata acuminate of the penis. Med Clin N Am. 1939;23:789–795

Steffen C. The men behind the eponym – Abraham Buschke and Ludwig Lowenstein: giant condyloma (Buschke–Loewenstein) Am J Dermatopathol. 2006;28(December (6)):526–536.

Chu Q.D., Vezeridis M.P., Libbey N.P., Wanebo H.J. Giant condyloma acuminatum (Buschke–Lowenstein tumor) of the anorectal and perianal regions. Analysis of 42 cases. Dis Colon Rectum. 1994;37:950–957

Balazs M. Buschke–Loewenstein tumour: a histologic and ultrastructural study of six cases. Virchows Arch A. 1986;410:83–92.

Balthazar E.J., Streiter M., Megibow A.J. Anorectal giant condyloma acuminatum (Buschke–Loewenstein tumor): CT and radiographic manifestations. Radiology. 1984;150:651–653.

Weils M., Robertson S., Lewis P., Dixon M.F. Squamous carcinoma arising in a giant condyloma associated with human papillomavirus type 6 and 11. Histopathology. 1988;12:319–323

Gissmann L., de Villiers E.-M., zur Hausen H. Analysis of human genital warts (condylomata acuminata) andother genital tumors for human papillomavirus type 6 DNA. Int J Cancer. 1982;29:143–146

Paraskevas K.I., Kyriakos E., Poulios E.E., Stathopoulos V., Tzovaras A.A., Briana D.D. Surgical management of giant condyloma acuminatum (Buschkee–Löwenstein tumor) of the perianal region. Dermatol Surg. 2007;33:638e44.

Brown S.B. The role of light in the treatment of non-melanoma skin cancer using methyl aminolevulinate. J Dermatolog Treat. 2003;14(Suppl. 3):11e4.

Giomi B., Pagnini F., Cappuccini A., Bianchi B., Tiradritti L., Zuccati G. Immunological activity of photodynamic therapy for genital warts. Br J Dermatol. 2011;164:448e51.

Machacek G.F., Weakley D.R. Giant condylomata acuminata of Buschke and Lowenstein. Arch Dermatol. 1960;82:41–47

Klaristenfeld D., Israelit S., Beart R.W., Ault G., Kaiser A.M. Surgical excision of extensive anal condylomata not associated with risk of anal stenosis. Int J Colorectal Dis. 2008;23(9):853–856

Cintron J.R. Buschke–Lowenstein tumor of the perianal and anorectal region. Semin Colon Rectal Surg. 1995;6:135–139.

Longacre T.A., Kong C.S., Welton M.L. Diagnostic problems in anal pathology. Adv Anat Pathol. 2008;15(5):263–278.

Agarwal, S., Nirwal, G. K., & Singh, H. (2014). Buschke-Lowenstein tumour of glans penis. International journal of surgery case reports, 5(5), 215–218.


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