Alpana Singh, Sugandha Dev, B D Banerjee


Objective : Assessment of maternal serum levels of vascular endothelial growth factor and placental growth factor in threatened abortion cases
with and without sub-chorionic hematoma.
Materials and Methods: 3 ml of peripheral blood sample was collected from each case. The plasma was separated and quantification of VEGF and
PlGF was done using ELISA kits.
Results: The VEGF levels were 24.90 ± 16.16 pg/ml if sub-chorionic hematoma was present and the levels were 31.29 ± 9.59 pg/ml in the absence of
hematoma. Hence the VEGF level was significantly decreased in the presence of sub-chorionic hematoma. Whereas the PlGF value was 281.76 ± 57.95
pg/ml in the presence of sub-chorionic hematoma and the value was 257.46 ± 71.01 pg/ml in the absence of hematoma with the p-value 0.29.


Threatened abortion, VEGF, PlGF, SCH

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Keskin U, Ulubay M, Dede M, Ozgurtas T. The relationship between the VEGF/sVEGFR-1 ratio and threatened abortion. Arch Gynecol Obstet 2015;291(3):557-61.

Cunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe JS, Hoffman BL, et al. Abortion. In Cunningham FG, Leveno KJ, Bloom SL, Spong CY, Dashe JS, Hoffman BL, et al, eds. William’s Obstetrics, 24th ed. Philadelphia: McGraw Hill; 2015:354-55.

Sotiriadis A, Papatheodorou S, Makrydimas G. Threatened miscarriage: evaluation and management. BMJ 2004;329(7458):152-55.

Makrydimas G, Sebire NJ, Lolis D, Vlassis N, Nicolaides KH. Fetal loss following ultrasound diagnosis of a live fetus at 6-10 weeks of gestation. Ultrasound Obstet Gynecol 2003;22:368-72.

Johns J, Hyett J, Jauniaux E. Obstetric outcome after threatened miscarriage with and without a hematoma on ultrasound. Obstet Gynecol 2003;102:483-87.

Elkholi DGEY, Nagy HM. Maternal serum concentrations of angiogenic and antiangiogenic factors in threatened miscarriage at 7-12 weeks’ gestation and the risk of adverse pregnancy outcomes. Middle East Fertil Soc J 2013;18:208-213.

Muttukrishna S, Swer M, Suri S, Jamil A, Calleja-Agius J, Gangooly S, et al. Soluble Flt-1 and PlGF: new markers of early pregnancy loss? PLoS One 2011;6(3):e18041.

Kutluer G, Ertargin P,Sankaya E. Low VEGF expression in conceptus material and maternal serum AFP and b- HCG levels as indicators of defective angiogenesis in first-trimester miscarriages. J Turkish- German Gynecol Assoc 2012;13:111-17.

Tseng JJ, Chou MM, Wen MC, Hsu SL. Differential expression of VEGF, PlGF and their receptors in placentae from pregnancies complicated by placenta accreta. Placenta 2006;27:70-78.

Andraweera PH, Dekker GA, Roberts CT. The vascular endothelial growth factor family in adverse pregnancy outcomes. Hum Reprod Update 2012;18(4):436-57.

Plaisier M, Dennert I, Rost E, Koolwijk P, van Hinsbergh VW, Helmerhorst FM. Decidual vascularization and the expression of angiogenic growth factors and proteases in first trimester spontaneous abortions. Hum Reprod 2009;24(1):185-97.

Jelkmann W. Pitfalls in the measurement of circulating vascular endothelial growth factor. Clin. Chem 2001;47:617–23.

Kou R, SenBanerjee S, Jain MK, Michel T. Differential regulation of vascular endothelial growth factor receptors (VEGFR) revealed by RNA interference: Interactions of VEGFR-1 and VEGFR-2 in endothelial cell signaling. Biochemistry 2005;44:15064–73.

Sukur YE, Goc G, Kose O, Acmaz G, Ozmen, Atabekoglu CS. The effects of subchorionic hematoma on pregnancy outcome in patients with threatened abortion. J Turk Gynecol Assoc 2014;15:239-42.

Maso G, De Seta F, Sartre A. First-trimester intrauterine hematoma and outcome of pregnancy. Obstet Gynaecol 2005;105:339-44.

Bamaniya J, Shah H, Singh P, Doshi H, Shah M, Ladola HM. Pregnancy outcome in patients with threatened abortion and abnormal early sonography markers: a prospective study. International Journal of Biomedical and Advance Research 2015;6(8):580-83.


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