Dr. Dhanya Nair, Dr. Pavan Acharya, Dr. Sanjay Chaudhari


Dengue infection is the most common arboviral infection in India. Most of the time, it is a self-limiting benign illness. At times, atypical manifestations can occur in Dengue infection of which cardiac involvement requires high degree of suspicion with timely treatment. It is postulated that; dengue rarely affects the heart. Medical literature has reports of isolated cases of atrioventricular conduction disorders (junctional rhythm and atrioventricular block), supraventricular arrhythmias, and myocarditis. On the other hand, the ventricular dysfunction associated with the acute phase of dengue hemorrhagic fever has been described by several authors and is probably under diagnosed in clinical practice.



Dengue fever, myocarditis, conduction abnormalities

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Rice CM. Flaviviridae: The viruses and their replication. In: Virology Fields BN, Knipe DM, Howley PM eds. 3rd ed., Philadelphia: Lippincott-Raven Publishers, 1996. p. 931-59.

Sam S-S, Omar SFS, Teoh B-T, Abd-Jamil J, AbuBakar S. Review of Dengue Hemorrhagic Fever Fatal Cases Seen Among Adults: A Retrospective Study. PLoS Negl Trop Dis 2013; 7:e2194.

Yacoub S, Wertheim H, Simmons CP, Screaton G, Wills B. Cardiovascular manifestations of the emerging dengue pandemic. Nat Rev Cardiol 2014; 11:335-45.

11. Friedrich MG, Sechtem U, Schulz-Menger J, Holmvang G, Alakija P, Cooper LT et al. Cardiovascular magnetic resonance in myocarditis: A JACC White Paper. J Am Coll Cardiol 2009; 53:1475-8.

Gupta VK, Gadpayle AK. Subclinical cardiac involvement in dengue haemorrhagic fever. JIACM 2010; 11:107-11.

Mustafa AS, Elbishbishi EA, Agarwal R et al. Elevated levels of interleukin-13 and IL- 18 in patients with dengue hemorrhagic fever. Immunol Med Microbiol 2001; 30:229- 33.

Vitarana T, de Silva H, Withana N et al. Elevated tumour necrosis factor in dengue fever and dengue haemorrhagic fever. Ceylon Med J 1991; 36:63-5.

King CA, Marshall JS, Alshurafa H et al. Release of vasoactive cytokines by antibody-enhanced dengue virus infection of a human mast cell/basophil line. J Virol 2000; 74:7146-50.

Satarasinghe R L, Arultnithy K, Amerasena NL et al. Asymptomatic myocardial involvement in acute dengue virus infection in a cohort of adult Sri Lankans admitted to a tertiary referral centre. Br J Cardiol 2007;14:171–3

SM Arif H Ahmed, KZ Khokon, AK Azad, MA Faizi; Dengue Haemorrhagic Fever with Bradycardia. J Medicine 2009;10:36-37.

6. Pesaro AE, D’Amico E, Aranha LF. Dengue: cardiac manifestations and implications in antithrombotic treatment. Arq Bras Cardiol 2007; 89:e12-5.


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