Dr. Pavan Acharya, Dr. Sanjay Chaudhari, Dr. Dhanya Nair


Clozapine is an atypical antipsychotic drug which is prescribed for treatment-refractory schizophrenia.1 The risk of adverse hematologic, cardiovascular, and neurologic effects has tempered its use, and reports of overdoses remain rare.2 Literature is relatively silent on antipsychotic overdose-induced coma.A few studies have so-far documented this rare neuropsychiatricpresentation, and all of them werefrom western countries. We presentthe first ever report of clozapine intoxication leading to about 36 hours ofcoma in an adult man from western India.


Clozapine overdose, Reversible coma, Antipsychotics.

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