RISK FACTORS FOR PRETERM DELIEVERIES (PTB) & FOETAL DISTRESS

Dr Monali Rewatkar, Dr Arun Tadas, Dr Kshama Kedar, Sanjay Agrawal, Supriya Bhoyar, Aditya Jain

Abstract


Background – Preterm birth (<37 completed weeks gestation) and very low birth weight (VLBW; <1500g) are associated with elevated maternal serum uric acid level. Uric acid is a marker of oxidative stress,tissue injury & endothelial dysfunction. It increases risk of preterm delieveries & can cause poor fetal outcome like foetal distress,IUGR babies etc

Materials & Methods - 100  women admitted in OBGY ward in last trimester of pregnancy were selected and follow up study was taken till delivery. Serum Uric acid level was estimated in Biochemistry clinical Laboratory on Autoanalyser in all subjects at term & values was estimated and compared with Mode of their delivery. Level of Serum uric acid was compared with IUGR & fetal distress & their association was correlated.

Result –                                                                            

Our study shows positive correlation between increase level of serum uric acid & Preterm deliveries  which shows association of hyperuricemia with Preterm labour. Current study also shows that there is positive and statistically significant relationship between hyperuricaemia in Pregnant women with  fetal  complications like IUGR, foetal distress, premature deliveries  etc .

Conclusion –  Increase serum uric acid level increases risk of preterm labours & fetal complications. So early screening for Serum uric acid level must be advised in pregnancy to prevent further risk like foetal distress & IUGR babies. 

 


Keywords


Preterm delieveries,Foetal distress, Serum Uric acid

Full Text:

PDF

References


Franco MCP, Christofalo DMJ, Sawaya AL, Ajzen SA, Sesso R. Effects of Low Birth Weight in 8-to 13-Year-Old Children - Implications in Endothelial Function and Uric Acid Levels. Hypertension. 2006;48:45–50. [PubMed] [Google Scholar]

Kaneshi T, Yoshida T, Ohshiro T, Nagasaki H, Asato Y, Ohta T. Birthweight and Risk Factors for Cardiovascular Diseases in Japanese Schoolchildren. Pediatr Int. 2007;49:138–43. [PubMed] [Google Scholar]

Feig DI, Nakagawa T, Karumanchi SA, Oliver WJ, Kang DH, Finch J, et al. Hypothesis: Uric Acid, Nephron Number, and the Pathogenesis of Essential Hypertension. Kidney Int. 2004;66:281–87. [PubMed] [Google Scholar]

. Lurbe E, Garcia-Vicent C, Torro MI, Aguilar F, Redon J. Associations of Birth Weight and Postnatal Weight Gain With Cardiometabolic Risk Parameters at 5 Years of Age. Hypertension. 2014;63:1326–32. [PubMed] [Google Scholar]

Park B, Park E, Cho S, Kim Y, Lee H, Min J, et al. The Association Between Fetal and Postnatal Growth Status and Serum Levels of Uric Acid in Children at 3 Years of Age. Am J Hypertens. 2009;22:403–08. [PubMed] [Google Scholar]

.

Parrish M, Griffin M, Morris R, et al. Hyperuricemia facilitates the prediction of maternal and perinatal adverse outcome in patients with severe/superimposed preeclampsia

Redman C, Beilin L, Bonnar J, Wilkinson R. Plasma urate measurements in predicting fetal death in hypertensive pregnancy. Lancet 1976; 1:1370 3.

Varma TR. Serum uric acid levels as an index of foetal prognosis in pregnancies complicated by pre existing hypertension and preeclampsia of pregnancy. Int J Gynaecol

Obstet 1982; 20:401 8

Krishna TS, Krishnamma M, Rajeswari DR, Rao V, Naidu JN, et al. Alterations of serum uric acid concetrations in preeclampsia. Int J Applied Bio Pharmaceutical Tech. 2015;6(2):165-7.

. Lancet M, Fisher IL. The value of blood uric acid levels in toxaemia of pregnancy. J ObstetGynaecol Br Emp. 1956;63:116-9.

Thanna RC, Choudhary R, Pathak S, Vamne A, Nigoskaret S. Level of serum acid in preeclampsia. International J Clinical Biochem. 2015;2(2):120-2.

Hawkins TL, Roberts LM, Brown MA. Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy: a retrospective cohort study. BJOG. 2012;119(4):484-92. .

Yassaee F. Hyperuricemia and perinatal outcomes in patients with severe preeclampsia. Int J Med Sci 2003; 28.

Martin JN, May WL, Magann EF, Terrone DA, Rinehart BK, Blake PG. Early risk assessment of severe preeclampsia: admission battery of symptoms and laboratory tests to predict likelihood of subsequent significant maternal morbidity. Am J Obstet Gynecol. 1999;180:1407-14.

Oken E, Kleinman KP, Rich-Edwards J, Gillman MW. A Nearly Continuous Measure of Birth Weight for Gestational Age Using a United States National Reference. BMC Pediatr. 2003;3:6. [PMC free article] [PubMed] [Google Scholar]

Lipkowitz M. Regulation of Uric Acid Excretion by the Kidney. Curr Rheumatol Rep. 2012;14:179–88. [PubMed] [Google Scholar]

Watanabe S, Kang DH, Feng L, Nakagawa T, Kanellis J, Lan H, et al. Uric Acid, Hominoid Evolution, and the Pathogenesis of Salt-Sensitivity. Hypertension. 2002;40:355–60. [PubMed] [Google Scholar]

Feig DI, Soletsky B, Johnson RJ. Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential Hypertension - A Randomized Trial. Jama-Journal of the American Medical Association. 2008;300:924–32. [PMC free article] [PubMed] [Google Scholar]

Lind T, Godfrey KA, Otun H, Philips PR. Changes in serum uric acid concentrations during normal pregnancy. Br J Obstet Gynaecol 1984; 91:128 32.


Refbacks

  • There are currently no refbacks.