DEVELOPMENT OF ULTRASONIC PULSER-RECEIVER FOR BONE DENSITY ASSESSMENT

Jyoti V Jethe, T S Ananthakrishnan, Aparna S Lakhe, Deepak P Patkar, Rajeev S Parlikar, G D Jindal

Abstract


Osteoporosis is a major health problem affecting millions of people every year, significantly in women after menopause and men over the age of 50
years. It is a deteriorated condition of the bone becoming weak and fragile due to decrease in mineral content such as calcium, resulting into high
risk of bone fracture. There are traditional methods for bone mineral density measurement using X-rays. In many recent studies ultrasound method
has emerged as a non-invasive method for bone density assessment and has been found to be helpful in mass screening high risk group of subjects.
In view of above, a low cost Ultrasonic Pulser-Receiver has been developed comprising four integrated circuit devices and a high voltage MOSFET
to be used in transmission mode. Rate generator chip (LM555) followed with a mono-stable chip (LM74121) generates trigger pulses of 2
microsecond duration with a pulse repetition frequency of 200 Hertz. These pulses are used to fire a MOSFET (5N120BND) through a Schmitt
trigger chip (MC33151) to generate 600Volt pulses of short duration to excite the ultrasonic transducer.
The transmitted ultrasound through the heel of the subject is received by another ultrasonic transducer and amplified using a quad operational
amplifier chip (OPA4354). The output signal is captured on a pen-drive through a digital storage oscilloscope for final processing on a personal
computer. Hardware development is reported in this paper.


Keywords


Bone mineral, osteoporosis, ultrasonic transducer, pulser-receiver.

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References


Lane JM, Riley EH and Philip Z. Osteoporosis: Diagnosis and treatment. Journal of Bone and Joint Surgery; 1996; 78:618-632.

The Asian Audit Epidemiology: costs and burden of osteoporosis in Asia. Report of International Osteoporosis Foundation; 2009; www.iofbonehealth.org/publications/ asian-audit-2009.html.

Holi MS, Radhakrishnan S, Swaranamani S and Jayavelan NA. Quantitative ultrasound technique for the assessment of osteoporosis and prediction of fracture risk; J. Pure Appl. Ultrason; 2005; 27: pp. 55-60.

Nieves JW, Golden AL, Siris E, Kelsey JL and Lindsay RT. Current calcium intake are related to bone mineral density of the hip and forearm in women aged 30–39 years. American Journal of Epidemiology; 1995; 141:pp.342–351.

Kleerekoper M, Villanueva AR, Stanciu J, Rao DS and Prafitt AM. The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures. Calcified Tissue International; 1985; 37:594-597.

Turner CH, Rho JY, Ashman RB and Cowin SC. The dependence of the elastic constants of cancellous bone upon structural density and fabric. Transactions of 34th Annual Meeting Orthopaedic Research Society; 1988; 13:74.

Kim SK, Yoo TK, Oh E, Kim DW. Osteoporosis risk prediction using machine learning and conventional methods. Proc. IEEE Conf. Eng. Med. Biol. Soc.; 2013; 2013:188–191.

Pisani P, Renna MD, Conversano F, Casciaro E, Muratore M, Quarta E, Paola MD and Casciaro S. Screening and early diagnosis of osteoporosis through X-ray and ultrasound based techniques. World J. Radiol; 2013; 5(11):398–410.

Nayak S, Roberts MS, Greenspan SL. Cost-effectiveness of different screening strategies for osteoporosis in postmenopausal women. Ann. Intern. Med; 2011; 155(11):751–761.

Wells PNT (1969) Physical principles of ultrasonic diagnosis. Academic, London.

Langton CM, Ali AV, Riggs CM, Evans GP and Bonfield W, A contact method for the assessment of ultrasonic velocity and broadband attenuation in cortical and cancellous bone. Clinical Physics and Physiologic Measurement; 1990; 11:243-249.

Njeh CF, Fuerst T, Diessel E, and Genant HK. Is quantitative ultrasound dependent on bone structure? A reflection. Osteoporosis. Int; 2001; 12(1): 1–15.

Svilainis L, Chaziachmetovas A and Dumbrava V.Half bridge topology 500 V pulser for ultrasonic transducer excitation. Ultrasonics; 2015; 59:79–85.

Langton CM, Palmer SB, and Porter RW. The measurement of broadband ultrasound attenuation in cancellous bone. Eng. Med; 1984; 13(2):89–91.

Krishnaveni S and Rajini V. Implementation of an economical and compact single mosfet high voltage pulse generator. Indian J. Sci. Technol.; 2015; 8:1–5.

Jaffar SA, Malakondaiah K and Gandole YB. Design of high voltage pulse generator and receiver circuit for ultrasonic velocity and absorption measurements in liquids. IJIREEICE; 2016; 4:88–90.

Hidayat D, Setianto, Syafei NS, and Wibawa BM. MOSFET-based high voltage short pulse generator for ultrasonic transducer excitation. AIP Conference Proceedings; 2018; 1927.


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