A CASE OF MULTIPLE INTRACRANIAL MENINGIOMAS

Dr. Vijay Karthik Bhogaraju, Dr. Krishna Sagar Gajula, Dr. Minakshi Dhar

Abstract


Meningiomas are the most common primary brain tumors in adults. Multiple meningiomas (MMs) or meningiomatosis are defined by the presence of at least two lesions that appear simultaneously or not, at different intracranial locations, without the association of neurofibromatosis. They present 1–9 % of meningiomas with a female predominance. The occurrence of multiple meningiomas is not clear. There are two main hypotheses for their development, one that supports the independent evolution of these tumors and the other, completely opposite, that suggests the propagation of tumor cells of a unique clone transformation, through cerebrospinal fluid. We present a case of a 60-year-old male patient who presented to the emergency department with weakness of right upper and lower limb. The patient was diagnosed with multiple meningiomas based on the magnetic resonance imaging of the brain. Multiple meningiomas is extremely rare in males.


Keywords


Multiple Meningiomas, vasogenic edema, hemiparesis.

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References


Ostrom QT, Gittleman H, Liao P, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro Oncol. 2014;16 Suppl 4:iv1-63.

DeAngelis LM. Brain tumors. N Engl J Med. 2001;344:114- 123.

H. Cushing and L. Eisenhardt, Meningiomas: Their Classification, Regional Behaviour, Life History and Surgical End Result, Charles C Thomas, Springfield, Ill, USA, 1938.

Pecori Giraldi F, Terreni MR, Andreotti C, et al. Meningioma presenting with Cushing’s syndrome: An unusual clinical presentation. Ann Neurol. 2003;53:138-142.

Razis P, Robinson D, Alberry R. Clinical presentation of “silent” meningiomas after general anaesthesia. Br J Anaesth. 1995;74:335-337.

Möller-Hartmann W, Herminghaus S, Krings T, et al. Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions. Neuroradiology. 2002;44:371-381.

Burtscher IM, Skagerberg G, Geijer B, et al. Proton MR spectroscopy and preoperative diagnostic accuracy: an evaluation of intracranial mass lesions characterized by stereotactic biopsy findings. AJNR Am J Neuroradiol. 2000;21:84-93.

Ott D, Hennig J, Ernst T. Human brain tumors: assessment with in vivo proton MR spectroscopy. Radiology. 1993;186:745-752.

Adamson AJ, Rand SD, Prost RW, et al. Focal brain lesions: effect of single-voxel proton MR spectroscopic findings on treatment decisions. Radiology. 1998;209:73-78.

D. S. Russel and L. J. Rubinstein, Pathology of Tumors of the Nervous System, Williams and Wilkins, Baltimore, Md, USA, 1977.

M. Turgut, S. Palaoglus, O. E. ¨ Osmam, and G. Gurc¸ay, “Multiples Meningiomas of the central nervous system without the stigmata of neurofibromatosis: clinical and therapeutic study,” Neurosurgical Review, vol. 20, no. 2, pp. 117–123, 1997.

G. Butti, R. Assietti, R. Casalone, and P. Paoletti, “Multiple Meningiomas: a clinical, surgical, and cytogenetic analysis,” Surgical Neurology, vol. 31, no. 4, pp. 255–260, 1989.

K. Kyoi, K. Yokoyama, T. Hoshida et al., “Mulitiple Meningioma,” No Shinkei Geka, vol. 11, no. 10, pp. 1099–1105, 1983.

D. Locatelli, A. Bottoni, C. Uggetti, and L. Gozzoli, “Multiple Meningiomas evaluated by computed tomography,” Neurochirurgia, vol. 30, no. 1, pp. 8–10, 1987.

M. Domenicucci, A. Santoro, D. H. D’Osvaldo et al., “Multiple intracranialMeningiomas,” Journal of Neurosurgery, vol. 70, no. 1, pp. 41–44, 1989.

M.Gelabert-Gonzalez, R. Leira-Muino, J. M. Fernandez-Villa et al., “Multiple intracranialMeningiomas,” Revista de Neurologia, vol. 37, no. 8, pp. 717–722, 2003.

P. Black, A. Morokoff, J. Zauberman, E. Claus, and R. Carroll, “Meningiomas: science and surgery,” Clinical Neurosurgery, vol. 54, pp. 91–99, 2007.

T. Gruber, A. O. Dare, L. L. Balos, S. Lele, and R. A. Fenstermaker, “Multiple Meningiomas arising during long-term therapy with the progesterone agonist megestrol acetate: case report,” Journal of Neurosurgery, vol. 100, no. 2, pp. 328–331, 2004.

T. S. Kim, J. K. Park, S. Jung et al., “Multiple intracranial Meningiomas,” Journal of Korean Neurosurgical, vol. 26, no. 12, pp. 1685–1691, 1997.

K.Mocker, H. Holland, P. Ahnert et al., “Multiplemeningioma with different grades of malignancy: case report with genetic analysis applying single-nucleotide polymorphism array and classical cytogenetics,” Pathology Research and Practice, vol. 207, no. 1, pp. 67–72, 2011.

M. S. M. Eljamel and P. M. Foy, “Multiple Meningiomas and their relation to neurofibromatosis,” Surgical Neurology, vol. 32, no. 2, pp. 131–136, 1989.

M. Salvati, E. Caroli, and L. Ferrante, “Zentrabl,” Neurochir, vol. 65, no. 4, pp. 180–184, 2004.

J. P. Sheehy and H. A. Crockard, “Multiple Meningiomas: a longtermreview,” Journal of Neurosurgery, vol. 59, no. 1, pp. 1–5, 1983.

M.Nakamura, F. Roser, J. Michel,C. Jacobs, andM. Samii, “The natural history of incidental Meningiomas,” Neurosurg, vol. 53, no. 1, pp. 62–70, 2003.

F. Koech, J. Orege, F. Ndiangui, B. Macharia, and N. Mbaruku, “Multiple Intracranial Meningiomas: A Review of the Literature and a Case Report” Hindawi Publishing Corporation; Case Reports in Surgery, Volume 2013, Article ID 131962.


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