Jai Prakash Yogi, Bushra Fiza, Maheep Sinha, Suraj Godara



Chronic kidney disease (CKD) is defined as irreversible loss of kidney function or estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2 for a period of 3 months or more. Uric acid (UA) is an end product of purine metabolism which is widely recognized as an independent risk factor of cardiovascular disease.

 Aims: This case control study was plan to assessed the correlation of serum Uric Acid with estimated Glomerular Filtration Rate (eGFR) in CKD patients.

 Methodology: In the study 50 diagnosed patients of CKD (stage 4 and 5), age between 20 to 60 years were enrolled. 50 age and sex matched healthy subjects constituted the control group. Serum Urea, Creatinine and uric acid were estimated for all the enrolled subjects. eGFR was calculated by Cockeroft and Gault formula. Results were compared between CKD patients and control group by applying suitable statistical test.

Result: Mean eGFR was significantly lower in CKD group (10.28± 4.18 ml/min/1.73m2, p <0.0001) as compared to healthy subjects. Mean serum uric acid were significantly higher in CKD patients (8.02 ± 1.84 mg/dl, p <0.0001) as compared to healthy subjects. A significant negative correlation was observed between Serum uric acid and eGFR on applying Spearmanns’s correlation (r = -0.463, p <0.0001).

Conclusion: High level of serum uric acid was found to be associated with significant fall in eGFR. Finding of the study suggest a strong association of hyperuricemia with progression of CKD. Therefore, uric acid can be considered as an independent risk factor for development of end stage renal disease (ESRD).


Chronic Kidney Disease, Uric Acid, eGFR,

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Yogi JP, Fiza Bushra, Godara Suraj, Sinha Maheep. Hematological profile and serum potassium levels in patients of chronic renal failure at a Tertiary Health Care Center. Int. j. clin. biomed. res. 2019;5(4):1-4.

Rymal E, Rizzolo D. Gout: a comprehensive review. JAAPA 2014; 27: 26-31, doi: 10.1097/

Wang J, Qin T, Chen J, Li Y, Wang L, Huang H, et al. Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies. PLoS One 2014; 9: e114259, doi: 10.1155/2014/852954.

Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk. N Engl J Med 2008; 359: 1811–1812, doi: 10.1056/ NEJMra0800885.

Feig DI. Uric acid: a novel mediator and marker of risk in chronic kidney disease? Curr Opin Nephrol Hypertens 2009; 18: 526–530, doi: 10.1097/MNH.0b013e328330d9d0.

Neuen B L, Chadban S T, Demaio A R, Johnson D W, Perkovic V. Chronic kidney disease and the global NCDs agenda. BMJ Glob Health 2017;2:e000380. doi:10.1136/bmjgh-2017-000380

Johnson RJ, Nakagawa T, Jalal D, Sánchez-Lozada LG, Kang DH, and Ritz E. Uric acid and chronic kidney disease: which is chasing which?. Nephrol Dial Transplant 2013; 28(9): 2221–2228.

Sarpal V. Serum Uric Acid Level in Patients with Chronic Kidney Disease: A Prospective Study. International Journal of Scientific Study | February 2017: Vol 4: Issue 11,Pg. 200-205.

National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidneydisease: evaluation, classifica-tion, and stratification. Am J Kidney Dis, 2002;39:1–266

Kohn, P. M. & Prozan, G. B. Hyperuricemia; relationship to hypercholesteremia and acute myocardial infarction. Journal of the American Medical Association 170, 1909–1912 (1959).

Viggiano, D. et al. Urate-Lowering Agents in Asymptomatic Hyperuricemia: Role of Urine Sediment Analysis and Musculoskeletal Ultrasound. Kidney & blood pressure research 43, 606–615, (2018).

Ames, B. N., Cathcart, R., Schwiers, E. & Hochstein, P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proceedings of the National Academy of Sciences of the United States of America 78, 6858–6862 (1981).

Hooper, D. C. et al. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America 95, 675–680 (1998).

Justicia, C. et al. Uric Acid Is Protective After Cerebral Ischemia/Reperfusion in Hyperglycemic Mice. Translational stroke research 8, 294–305, (2017).

Chen Z, Ding Z, Fu C, Yu C, Ma G. Correlation Between Serum Uric Acid and Renal Function in Patients With Stable Coronary Artery Disease and Type 2 Diabetes. J Clin Med Res. 2014;6(6):443-450

Kamel M, Sharkawy ME, Afifi E, Ali M, Ramadan A. Impact of Hyperuricemia on Cardiovascular System in ESRD Patients. The Egyptian Journal of Hospital Medicine (July 2013) Vol. 52, Page 624–629

Babić N, Avdagić N, Kurspahić E, Valjevac A, Začiragić A. Prediction equations based on serum creatinine concentrations in estimating glomerular filtration rate in patients with chronic kidney diseases (Prediction equations in estimating glomerular filtration rate in patients with chronic kidney diseases). Folia Medica 2014; 49 No 1:59-67

Tsai C W, Lin S Y, Kuol C C, Huangl C C. Serum Uric Acid and Progression of Kidney Disease: A Longitudinal Analysis and Mini- Review. PLOS ONE | January 20, 2017 DOI:10.1371/journal.pone.0170393

Zhang YF, He F, Ding HH, Dai W, Zhang Q, Luan H, et al. Effect of uric-acid-lowering therapy on progression of chronic kidney disease: a meta-analysis. J Huazhong Univ Sci Technolog Med Sci 2014; 34: 476–481, doi: 10.1007/ s11596-014-1302-4.

Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, et al. A role for uric acid in the progression of renal disease. J Am Soc Nephrol 2002; 13: 2888–2897, doi: 10.1097/01.ASN.0000034910.58454.FD.

Chini LSN, Assis LIS, Lugon J.R. Relationship between uric acid levels and risk of chronic kidney disease in a retrospective cohort of Brazilian workers. Brazilian Journal of Medical and Biological Research (2017) 50(9): e6048,


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