Dr. Prachee Singh


Objective- To understand  the importance of CRP test in diagnosis of neonatal sepsis, Rheumatoid arthritis and other inflammatory presentation brought to Medical college hospital .

Introduction- One hundred samples of patients were screened for CRP those who are having various ailments in the Medical college hospital , we have screened the serum samples by latex agglutination test. CRP appears and disappears more quickly than changes in ESR.  Therefore the  CRP is considered the useful nonspecific biochemical marker of inflammation measurement. CRP contributes importantly to various disease diagnosis.

Results & Observation- The study is based on 100 samples collected from different specialty in duration of three months. Neonatal sepsis is confirmed in two cases out of four .The study was useful in finding out indication of arthritis  in 20% cases of  orthopedic dept. The study was also useful in ascertaining the impact of drugs used in post -surgery cases and also in cases of general medicine.


CRP ( C- reactive protein)

Full Text:



- Tillett WS, Francis T , "Serological reactions in pneumonia with a nonprotein somatic fraction of pneumococcus". The Journal of Experimental Medicine. 52(4): doi:10.1084/jem.52.4.561. PMC 2131884. PMID 19869788.

-Bray C, Bell LN, Liang H, Haykal R, Kaiksow F, Mazza JJ, Yale SH (December 2016). "Erythrocyte Sedimentation Rate and C-reactive Protein Measurements and Their Relevance in Clinical Medicine" . Wisconsin Medical Journal (WMJ). 115 (6): 317–21. PMID 29094869

-, Haslauer et al, Gene expression of catabolic inflammatory cytokines peak before anabolic inflammatory cytokines after ACL injury. Journal of Inflammation 2014, 11:34

- Jessica J. Chiang, MA etal ,Socioeconomic Status, Daily Affective and Social Experiences, and Inflammation During Adolescence, Psychosomatic Medicine , March 2015 :

-Thompson D, Pepys MB, Wood SP (February 1999). "The physiological structure of human C-reactive protein and its complex with phosphocholine". Structure. 7 (2): 169–77. doi:10.1016/S0969-2126(99)80023-9. PMID 10368284.

- C-Reactive Protein - A critical Review M. Ram Mohan Rao and Syam D Gopal ,Department of Microbiology, SRMC, Akathumuri, Varkala, Kerela, Int.J.Curr.Microbiol.App.Sci (2015) 4(12): 55-61

- Markanday A. Acute Phase Reactants in Infections: Evidence-Based Review and a Guide for Clinicians. Open Forum Infect Dis. 2015;2(3):ofv098. Published 2015 Jul 3. doi:10.1093/ofid/ofv098

- Pepys MB, Hirschfield GM. C-reactive protein: a critical update [published correction appears in J Clin Invest. 2003 Jul;112(2):299]. J Clin Invest. 2003;111(12):1805–1812. doi:10.1172/JCI18921

- Hisamuddin E, Hisam A, Wahid S, Raza G. Validity of C-reactive protein (CRP) for diagnosis of neonatal sepsis. Pak J Med Sci. 2015;31(3):527–531. doi:10.12669/pjms.313.6668

-.Santonocito C, De Loecker etal ,C-reactive protein kinetics after major surgery. Anesth Analg. 2014 Sep;119(3):624-9. doi: 10.1213/ANE.0000000000000263

-Van Ree RM, Oterdoom LH etal ,Elevated levels of C-reactive protein independently predict accelerated deterioration of graft function in renal transplant recipients. Nephrol Dial Transplant. 2007 Jan;22(1):246-53. Epub 2006 Sep 23.

- M. Saljoughian, The Role of C-Reactive Protein,Alta Bates Summit Medical Center,Berkeley, California ,US Pharm. 2008;33(7):HS12-HS15

-Arthurs ZM, Andersen C, Starnes BW etal , A prospective evaluation of C-reactive protein in the progression of carotid artery stenosis. J Vasc Surg. 2008 Apr;47(4):744-50; discussion 751. doi: 10.1016/j.jvs.2007.11.066. Epub 2008 Mar 4

- Lusic, I., Radonic, V., Pavelin, S., Bilic, Is C-reactive protein a better predictor of recurrent carotid disease following carotid endarterectomy than established risk factors for atherosclerosis? Vasa, 35: 221 225:2006

- Kim, J.S., Kang, T.S., Kim etal , Significant association of C-reactive protein with arterial stiffness in treated nondiabetic hypertensive patients. Atherosclerosis, 192: 401 406: 2007

- Wolford, J.K., Hanson, R.L. 2003. A Creactive protein promoter polymorphism is associated with type 2 diabetes mellitus in Pima Indians.

- Yasojima, K., Schwab, C., McGeer, E.G., McGeer, P.L. Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer s disease. Brain Res., 887: 80 89:2000

- Sproston NR, Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Front Immunol. 2018;9:754. Published 2018 Apr 13. doi:10.3389/fimmu.2018.00754

- Bray C, Bell LN, Liang H, Haykal R, Kaiksow F, Mazza JJ, Yale SH (December 2016). "Erythrocyte Sedimentation Rate and C-reactive Protein Measurements and Their Relevance in Clinical Medicine" (PDF). Wisconsin Medical Journal (WMJ). 115 (6): 317–21. PMID 29094869

- C-Reactive Protein, the Metabolic Syndrome, and Risk of Incident Cardiovascular Events,Paul M Ridker,Julie E. Buring,Nancy R. Cook, and Nader Rifai. 2003;107:391–397

- Alhabbab R.Y. (2018) C-Reactive Protein (CRP) Latex Agglutination Test. In: Basic Serological Testing. Techniques in Life Science and Biomedicine for the Non-Expert. Springer, Cham

- Rajesh Kumar Meena et al, CLINICAL UTILITY OF ESR AND CRP: A SYSTEMATIC LITERATURE REVIEW, IAJPS 2018, 05 (08), 7603-7610


  • There are currently no refbacks.