CORRELATION STUDY OF BLOOD G6PD LEVELS WITH DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS

Dr Ruchika Priyadarsini, Prof Dr Pramila Kumari Mishra

Abstract


 Glucose -6-phosphate dehydrogenase (G6PD) is the rate limiting enzyme of pentose phosphate pathway which produce NADPH , involved in lipid biosynthesis. Insulin is an anabolic hormone having profound influence on various key enzymes involved in lipid metabolism. The current study was designed to evaluate serum G6PD activity and its association with  dyslipidemia in Type 2 DM. Total 100 diabetic patients and 100 age and sex matched healthy controls were included in the study. Blood G6PD was measured by chemical method. Estimation of  cholesterol , TG , HDL, LDL was done in autoanalyzer  . Statistical analysis was done by SPSS Version 20 software. Mean G6PD levels was significantly higher in diabetic cases . Increased G6PD levels correlates positively with TC,TG,LDL, however HDL shows a negative correlation. Increased activity of G6PD in diabetic cases, alters lipid homeostasis which leads to atherogenic abnormalities. Estimation of serum G6PD & its correlation with dyslipidemia can highlight its role in regulating lipid status in diabetes mellitus patients .


Keywords


G6pd, Dyslipidemia, NADPH

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References


Shetty, P.(2012). Public Health: India Diabetes Time Bomb. Nature,486(8).14- 16. doi 10: 1038/485s14a (Newspaper online) 2012 may 16 cited 2012 September (8) Available.

Boden ,G., Chen, X., Capulong ,E. &Mozzoli, M .(2010). Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes. Diabetes ,50, 810–816.

Kuhlmann, J.et al,2010. Intramyocellular lipid and insulin resistance: a longitudinal in vivo 1H-spectroscopic study in Zucker diabetic fatty rats; Diabetes ,50,138–144.

Third report on NCEP Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults(Adult Treatment Panel III) Final Report. (2002). Circulation ,106(25), 3143-3421.

Varley’s Practical Clinical Biochemistry. 6th Edition, Heinemann Professional Publishing Ltd. London

Joshi, S.R.et al., 2014. High prevalence of G6PD deficiency in Vataliya Prajapati Community in Western India . Haematology, 31 , 57-60 .

M. Stahlman, B. Fagerberg, M. et al.,2013. Dyslipidemia, but not hyperglycemia and insulin resistance, is associated with marked alterations in the HDL lipidome in type 2 diabetic subjects in the DIWA cohort: Impact on small HDL particles. Biochim. Biophys. Acta 1831,1609-1617.

Uttra,K.M , Devrajani,B.R,et al,.2009. Lipid Profile of Patients with Diabetes mellitus (A Multidisciplinary Study) .World Applied Sciences Journal ,12 (9): 1382-1384.

Adu ,M.E . Serum lipid abnormalities in type 2 diabetes mellitus . (2014). African Journal of Cellular Pathology , 3: 5-8.

Bhatt, R.D., Lochan, K.(2015). Types of Dyslipidemia in Type 2 DM Patients of Bhubaneswar region . ACCLM , 1(1): 33-36 .

Mahato,R.V., Gyawali,P., et al., 2011. Association between glycaemic control and serum lipid profile in type 2 diabetic patients: Glycated haemoglobin as a dual biomarker .Biomedical Research ,22 (3): 375-380 .

Dessi, S., B. Batetta, O. Spano, D. Pulisci, M. F. Mulas, S. Muntoni, M. Armeni, C. Sanna, R. Antonucci, and P. Pani. 1992. Serum lipoprotein pattern as modified in G6PD-deficient children during hemolytic anaemia induced by fava bean ingestion. Int. J. Exp. Pathol, 73,157–160.


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