EXTRA-NEURAL PERINEURIOMA OF MANDIBLE : A RARE PRESENTATION

Dr Sumanta Das, Dr Charanjeet Ahluwalia, DR Rashmi Arora

Abstract


Perineurioma is a soft tissue tumor composed of cells resembling normal perineurium.Lazarus and Trombetta first described it in 1978 on the basis of ultrastructural findings. All perineuriomas express antigens that are identical to normal perineurium of nerve. Soft tissue perineurioma is most commonly seen in extremities and trunk. It has been very rarely described in gingiva, mandible, lips, retrotonsillar mucosa and maxillary vestibule. We present a case of soft tissue type perineurioma arising in mandible, an extremely rare site.


Keywords


Perineurioma, tumor, antigens

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References


Macarenco RS, Ellinger F, Oliveira AM. Perineurioma : a distinct and underrecognized peripheral nerve sheath neoplasm. Arch Pathol Lab Med 2007;131:625-36.

Lazarus SS, Trombetta LD. Ultrastructural identification of a benign perineurial cell tumor. Cancer 1978;41:1823-9.

Pina-Oviedo S, Ortiz-hidalgo C. The normal and neoplastic perineurium: a review. Adv Anat Pathol 2008;15:147-64

Giannini C, Scheithauer BW, Jenkins RB, et al. Soft tissue perineurioma. Evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature. Am J Surg Pathol. 1997;21:164–173.

Hornick JL, Fletcher CD. Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol. 2005;29:845–858.

Sciot R, Dal Cin P, Hagemeijer A. Cutaneous sclerosing perineurioma with cryptic NF-2 gene deletion. Am J Surg Pathol 1999;23:849-53.

Thomas PK, Ochoa J. Microscopic anatomy of peripheral nerve fibers. In: Dick PJ, Thomas PK, Lambert EH, et al, eds. Peripheral Neuropathy. Vol 1. Philaldelphia: Saunders; 1984:39–96.

Kim JH, Kim JH, Park JA, et al. Blood-neural barrier: intercellular communication at glio-vascular interface. J Bioch Mol Biol. 2006; 39:339–345.

Reina MA, Lo´pez A, Villanueva MC, et al. Morfologı´a de los nervios perife´ricos, de sus cubiertas y de su vascularizacio´n. Rev Esp Anestesiol Reanim. 2000;47:464–475.

Burkel WE. The histological fine structure of perineurium. Anat Rec. 1967;158:177–189.

Koutlas IG, Scheithauer BW, Folpe AL. Intraoral perineurioma,soft tissue type: Report of five cases, Including 3 intraosseous examples, and Review of the literature. Head Neck Pathol 2010;4:113-20.

Kusama K, Iwamoto A, Mikuni M, et al. A case of central perineurioma (Lazarus and Trombetta) of the mandible. J Nihon Univ Sch Dent. 1981;23:10–17

Barrett AW, Hopper C, Landon G. Intra-osseous soft tissue perineurioma of the inferior alveolar nerve. Oral Oncol. 2002;38:793–796

Mentzel T, Kutzner H. Reticular and plexiform perineurioma: clinicopathological and immunohistochemical analysis of two cases and review of perineurial neoplasms of the skin and soft tissues. Virchows Arch. 2005;447:677–682

Graadt van Roggen JF, McMenamin ME, Belchis DA, et al. Reticular perineurioma: a distinctive variant of soft tissue perineurioma. Am J Surg Pathol. 2001;25:485–493.

Ide F, Shimoyama T, Horie N, Kusama K. Comparative ultrastructural and immunohistochemical study of perineurioma and neurofibroma of the oral mucosa. Oral Oncol. 2004;40:948–953.

Meer S, Coleman H, Altini M. Intraoral perineurioma: report of a case with a review of the literature. Oral Dis. 2003;9:99–103.

Folpe AL, Billings SD, McKenney JK et al. Expression of claudin-1, a recently described tight junction-associated protein,distinguishes soft tissue perineurioma from potential mimics. Am J Surg Pathol 2002;26:1620-6.

Yamaguchi U., Hasegawa T, Hirose T et al. Sclerosing perineurioma: a clinicopathological study of five cases and diagnostic utility of immunohistochemical staining for GLUT-1. Virchows Arch 2003;443:159-63.


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