Sandeep. C, Mukunth. K, Prabhakar Reddy


Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease that causes joint destruction and functional disability. In this study we take
200 normal individual and 200 rheumatoid arthritis patient. For the biochemical parameter to be analyzed, blood samples were drawn from the
anticubital vein avoiding venostasis. In all subjects a blood sample was collected after an overnight fast.The study found a significant decreased
Hb% and significantly lower levels of serum iron &TIBC in RA patients as compared to control. The result suggested that routine dietary
supplementation with multivitamins and a trace element is appropriate in rheumatoid arthritis patients.


Rheumatoid arthritis, Iron, TIBC, Uric acid, Anemia

Full Text:



Pincus T, Callahan LF. Reassessment of twelve traditional paradigms concerning the diagnosis, prevalence, morbidity and mortality of rheumatoid arthritis. Scand J Rheumatol. 1989;18(Suppl79):67–96. 2

. Sherrer YS, Bloch DA, Mitchell DM, Young DY, Fries JF. The development of disability in rheumatoid arthritis. Arthritis Rheum. 1986;29(4):494–500.

Pepys MB. Aspects of the acute phase response. The C-reactive protein system. In : Lachmann PJ, Peters DK, editors. Clinical Aspects of Immunology. Oxford: Blackwell Scientific Publications; 1982. p. 50–71.

Kushner I, Rzewnicki DL. The acute phase response: general aspects. Baillieres Clin Rheumatol 1994;8:513–30. [CrossRef]

Graudal N, Tarp U, Jurik AG, Galløe AM, Garred P, Milman N, et al. Inflammatory patterns in rheumatoid arthritis estimated by the number of swollen and tender joints, the erythrocyte sedimentation rate, and hemoglobin: longterm course and association to radiographic progression. J Rheumatol 2000;27:47–57.

Yildirim K, Karatay S, Melikoglu MA, Gureser G, Ugur M, Senel K. Associations between acute phase reactant levels and disease activity score (DAS28) in patients with rheumatoid arthritis. Ann Clin Lab Sci 2004;34:423–6. 7. Nassonov EL, Samsonov MY, Chichasova NV, Nikiphorova EL, Tilz GP, Demel U, et al. Soluble adhesion molecules in rheumatoid arthritis. Rheumatology (Oxford) 2000;39:808–10.

Lee DM, Weinblatt ME. Rheumatoid arthritis. Lancet 2001;358:903-11.

Schoels M1, Aletaha D, Smolen JS, Wong JB. Comparative effectiveness and safety of biological treatment options after tumour necrosis factor α inhibitor failure in rheumatoid arthritis: systematic review and indirect pairwise meta-analysis. Ann Rheum Dis 2012;71:1303-8.

Fransen J, van Riel PL. The Disease Activity Score and the EULAR response criteria. Clin Exp Rheumatol 2005;23(5 Suppl 39):S93-9.

Wolfe F. Comparative usefulness of C-reactive protein and erythrocyte sedimentation rate in patients with rheumatoid arthritis. J Rheumatol 1997;24:1477-85.

Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 340:448-54.

Sang- Cheol Bae, MD, PhD, MPH, Soo- Jin Kim, MSc, Mi-Kyung Sung, PhD. (2003), Inadequate Antioxidant Nutrient Intake and Altered Plasma Antioxidant Status of Rheumatoid Arthritis Patients. Journal of the American College of Nutrition. 22, 4, 311-315.

Pepys MB. Aspects of the acute phase response. The C-reactive protein system. In : Lachmann PJ, Peters DK, editors. Clinical Aspects of Immunology. Oxford: Blackwell Scientific Publications; 1982. p. 50–71.

van Leeuwen MA, van Rijswijk MH, van der Heijde DM, Te Meerman GJ, van Riel PL, Houtman PM, et al. The acute-phase response in relation to radiographic progression in early rheumatoid arthritis: a prospective study during the first three years of the disease. Br J Rheumatol 1993;32 Suppl 3:9–13.

Lansbury J. Report of a three-year study on the systemic and articular indexes in rheumatoid arthritis; theoretic and clinical considerations. Arthritis Rheum 1958;1:505–22. [CrossRef]

Hamilton, P J. The hematology laboratory and the rheumatologist. Clin Rheum Dis. 1983; 9:69.

Al Arfaj AS. Serum uric acid and radiographic osteoarthritis. J Pak Med Assoc.2003; 53: 187-189.

Shweta Dwivedi et al. Levels of Hemoglobin, ESR, Iron & TIBC in Rheumatoid Arthritis Patients Compared with Normal Individuals. JMSCR Volume 04 Issue 03 March Page 9807.

Kamanli A. Naziroglu M, AydileKN, Hacievliyagil C. Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid arthritis. Cell Biochem Funct. 2004: 22 (1): 53-7.

Vinod Ravindran, Sandeep jain and Dinesh S. Mathur. The differentiation of aneamia in rheumatoid arthritis: parameters of iron- deficiency in an Indian rheumatoid arthritis population; Rheumatology International.2007.

Dallaiio G, Means RT. Effect of oxidative stress on human erythroid colony formation: modulated by gammainterferon. The Journal of Laboratory and Clinical Medicine.2003; 141:395-400.

Ayhan Kamanll, Mustafa Nazlroglu, Nurettin Aydllek, Cengiz Haclevllyagill. Plasma lipid-peroxidation and antioxidant levels in patients with rheumatoid arthritis. Cell Biochemistry and function. 2003; 22, 1,53-57.

F. Karatas, I. Ozates, H. Canatan, M. Karatepe and R. Colok. Antioxidant status and lipid-peroxidation in patients with rheumatoid arthritis. Indian J Med Res. 2003:118; 178-181.

Akyol O, Isci N, Temel I, Ozgocmen S, UzE. (2001). The relationship between plasma and erythrocyte antioxidant enzymes and lipid peroxidation in patients with rheumatoid arthritis. Joint Bone Spine; 68: 311-7.

Hassan MQ, Hadi RA, AI- Rawi ZS, Padron VA, Stohs SJ. The glutathione defense system in the pathogenesis of rheumatoid arthritis. J Appl Toxicol.2001; 21(1): 69-73.

Agarwal Sumeet; Mishra Ramnath; Aggarwal Amia. Anemia in rheumatoid arthritis: high prevalence of iron- deficiency anemia in Indian patients. Rheumatology International. 2006:26: 12; 1091-1095


  • There are currently no refbacks.