COMPARATIVE STUDY OF SERUM ALBUMIN AND URIC ACID IN GESTATIONAL DIABETES MELLITUS WITH HEALTHY PREGNANCY

Dr. Hem Priya, Dr. Yogita Soni, Praveen Kumar

Abstract


Background: A woman can be diagnosed with gestational diabetes when glucose intolerance continues beyond 24 to 28 weeks of gestation. 1 in 3 women with diabetes were of reproductive age. 21.3 million of live births had some form of hyperglycemia in pregnancy.

Methodology: This study was carried out in Department of Biochemistry and conducted on 50 clinically positive diagnosed women with GDM in their 2nd trimester of pregnancy represented as study group and 50 healthy pregnant women clinically negative diagnosed with GDM during the 2nd trimester as control group aged between 20-35 years attending Antenatal clinic part of Department of Gynecology and Obstetrics. Serum Albumin and Uric Acid were estimated.

Result: Mean serum albumin level was decreased to 3.418gm/dl and mean serum concentration of uric acid was increased to 4.30mg/dl as compared to control group(3.5gm/dl & 3.03mg/dl).

Conclusion: In this study, we found that gestational diabetes had significantly increased concentration of uric acid and a significantly decreased concentration of albumin than healthy pregnant women. Hyperuricemia seen in GDM could be caused by the effects of insulin on the kidneys. Decreased albumin level in insulin resistant subjects aggravates cardiovascular complications.

 

 

 

 

 

 

 


Keywords


Gestational Diabetes Mellitus, Albumin, Uric Acid.

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References


Malik Mumtaz. Gestational Diabetes Mellitus. Malaysia Journal of Medical Science. 2000 Jan; 7(1): 4–9.

IDF Diabetes Atlas 8th ed Brussels, Belgium: International Diabetes Federation; 2017.

De Groot LG, Cheousos G, Dungan K. Endocrinology of pregnancy South Dartmouth: Endotext; 2000.

Baumann MU, Deborde S, Illsley NP. Placental glucose transfer and fetal growth. Endocrinre. 2002; 19: 13-22.

Tietz NW. Clinical guide to laboratory tests 3rd Phildelphia Pa: W B Saunders: 1995: 22-24.

Doumas BT, Watson WA, Biggs ahg. Albumin standards and the measurements of serum albumin with bromocresol green. Clinical chemistry acta. 1971; 31: 87-96.

Henry RJ. Clinical chemistry- principles and techniques. 2nd ed: Harper and Row; 1974.

McGrowderl D, Grant K, Irving R, Gordon L, Crawford T, Lindo RA et al. Lipid profile and clinical characterstics of women with gestatioal diabetes mellitus and preeclampsia. JMB 2009; 28(2): 72-81.

Nagalakshmi CS, Devaki RN, Akila P, Suma KB, Prashant V, Suma MN et al. Exploration of the clinic-biochemical parameters to explain the altered renal mechanisms in gestational diabetes mellitus CDR. 2012; 3812.

Ishizaka N, Ishizaka Y, Nagai R, Toda E, Hashimoto H, Yamakado M. Association between serum albumin, carotid atherosclerosis and metabolic syndromes in Japanese individuals. Atherosclerosis. 2007; 193: 373-379.

Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes and cardiovascular disease? Arteriosclerosis thromb vasc boil. 2004; 24: 816-823.

Beddhu S, Kaysen GA, Yan G, Sarnak M, Agodoa L, Ornt D, Cheunq AK. Association of serum albumin and atherosclerosis in chronic hemodialysis pateitns. Am j kidney dis. 2002; 40(4): 721-7.

Bhonsle HS, Singh SK, Srivastva G, Boppana R, Kulkarni MJ. Albumin competitively inhibits glycation of less abundant proteins, protein and peptide 2008; 15: 663-7.

Cho HM, Kim HC, Lee JM, Choi DP, Suh I. Association between serum albumin levels and metabolic syndrome in a rural population of korea. J prev med public health. 2012; 45: 98-104.

Gungor ES, Danisman N, Mollamahmutoglu L. Relationship between serum uric acid, creatinine, albumin and gestational diabetes mellitus. Clinical chemistry and laboratory medicine. 2006; 44: 974-977.

Maged AM, Moety GAF, Mostafa WA, Hamed DA. Comparative study between different biomarkers for early prediction of gestational diabetes mellitus. Journal of maternal fetal neonatal medicine 2014; 27(11): 1108-1112.

Pundalikand B, Suchitra T. Uric acid levels in early pregnancy as a predictor of preeclampsia and gestational diabetes mellitus. International journal of recent scientific research. 2016; 6(6): 4611-15.

Singh U, Mehrotra S, Singh R, Sujata , Gangwar ML, Shukla B. Serum uric acid: A novel risk factor for gestational diabetes mellitus. International journal of medicine research and review. 2015; 3(1): 10-15.

Moleda P, Fronczyk A, Safranow K, Majkowska L. Is uric acid a missing link between previous gestational diabetes mellitus and development of type II diabetes at a later time of life? Plos one. 2016; 11(5): e0154921.

Laughon SK, Catovr J, Provis T, Roberts JM, Gandley RE. Elevated first trimester uric acid concentrations are associated with the development of gestational diabetes. American journal of obstetrics and gynecology. 2009; 201(4): 402e1-e5.

Gharib MNE, Mahfouz AE, Morad MA, Farahat MA. Prediction of gestational diabetes by measuring first trimester maternal serum uric acid concentration. Journal of basic and clinical reproductive sciences. 2013; 2(1): 28-31.

Waring WS. Antioxidant in prevention and treatment of cardiovascular disease. Proc R Coll Physicians Edin. 2001; 31: 288-92.

Warig WS, Webb DJ, Maxwell SR. Systemic uric acid administration increase serum antioxidant capacity in healthy adults. J cardiovasc pharmacol. 2001; 38: 365-71.


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