TO STUDY THE CORRELATION OF ENDOGENOUS SEX STEROID HORMONES LEVELS WITH METABOLIC SYNDROME IN POST MENOPAUSAL FEMALES

Vijeta Grewal, Ritu Kumari, Rajesh Satyapal Taneja, Pankaj Sheoran

Abstract


Objective: to study the correlation of endogenous sex steroid hormones levels with metabolic syndrome in postmenopausal females
Study methodology: In this case control cross sectional study 100 postmenopausal women were enrolled (50 cases and 50 control with and without metabolic syndrome respectively). Detailed history and medical examination were done. Serum evaluation for lipid profile, fasting blood sugar, SHBG, estradiol and testosterone was done. Metabolic syndrome was defined according to definition of NCEP-ATP III with ethnic specificity for Asian Indian.
Results: Hormone profile had significantly higher value of serum testosterone both total (p= 0.027) and free (p= 0.00066) in cases than controls but no significant difference in levels of estradiol (p= 0.983). Also, serum SHBG levels (p= <0.001) were significantly low in cases. Negative correlation of SHBG with systolic BP (p= 0.032, r= -.303) and testosterone with diastolic BP (p= 0.021, r= -.326) in cases and positive correlation of SHBG with fasting blood sugar in controls with statistical significance (p= 0.021, r= .326).
Conclusion: Testosterone and SHBG were significantly associated with the emergence of metabolic syndrome in postmenopausal females. No relation was found between estradiol and emergence of metabolic syndrome.


Keywords


Endogenous Sex Steroid Hormone, Metabolic Syndrome, Postmenopausal Women

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