STUDY OF CLINICAL PROFILE AND OUTCOME OF DENGUE FEVER WITH RENAL INVOLVEMENT

Dr..Aher Sangeeta, Dr Ashok kumar, Dr .Nagesh Zalte

Abstract


Dengue is a growing public health problem in India and acute kidney injury (AKI) is one of the least studied complications1. Dengue virus infection can exhibit a wide spectrum of renal dysfunction including tubular dysfunction (dyskalemia, dysnatremia, and acute tubular necrosis), and less commonly glomerular injury (ie microscopic hematuria or proteinuriain and acute kidney injury (AKI)3. Data from previous reports have shown that the incidence could be up to 80%.This study is undertaken to evaluate common modes of clinical presentation and renal complications in our hospital and correlate these features with lab findings which may help us in early diagnosis and better case management to reduce mortality.

1.The Aim of this study

a.To study Incidence ,Prevalence and Outcome of Renal Involvement in Dengue Fever

b. To study the impact of AKI on the length of hospital stay and mortality.

2.Materials and methods: It is prospective observational study carried out in a Tertiary Care Hospital. The study population consisted 50 patients of age group above 18 years .Inclusion criteria: All the adult patients were admitted in General Medicine ward in NAIR Hospital  with Dengue NS1/IgM/IgG/RT-PCR test positive were included in study. Exclusion criteria: Mixed infections and also Patients with pre-existing Renal Diseases were excluded from thestudy.Statisticalanalysis: Data was collected using a predesigned pretested questionnaire, data was entered in Microsoft Excel and was analysed using SPSS version 20 and EpiInfo version 7.2.1.. Significance level was set at P < 0.05. Results were analysed and discussed.

Conclusion: Out of all 50 cases, 10 patients had Acute kidney injury(20%).There was no any significant association between the gender and presence of AKI (p =0.89).Highly significant association was seen between the diagnosis of dengue type and presence of AKI (p <0.001).Our study observed significant association between the duration of hospital stay and presence of AKI (p =0.013),These parameters conclude that though dengue associated AKI is aseverecondition, if managed properly it resolves after a period of time.


Keywords


dengue infection, renal dysfunction, glomerular injury

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References


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