ROLE OF MICROALBUMINURIA AS A SEVERITY AND PROGNOSTIC INDICATOR IN PATIENTS WITH ACUTE ISCHAEMIC STROKE

Dr. Lalit Choudhary, Dr. Rajmani

Abstract


Objective: To find association between microalbuminuria and stroke severity based on NIHSS and Modified Rankin Scale. Material and Methods: A total of 100 cases and 100 controls that were age/sex matched and admitted during March 2018 to October 2019 were taken into study based on inclusion and exclusion criteria. Urine for microalbumin is tested at the time of admission. Stroke severity was assessed by NIHSS score on admission and prognosis by mRS score at discharge /death. Results: Microalbuminuria is seen in 65%of cases and 8% of controls, (P <0.001). Among100 stroke patients, 100% patients with very severe NIHSS score and 78.26% patients with severe NIHSS score were with microalbuminuria (P <0.001), thus predicting seriousness of stroke in patients with microalbuminuria. Conclusion: We found that MA is an independent risk factor and potential prognostic marker in acute ischemic stroke.


Keywords


microalbuminuria, NIHSS score, mRS score, ischemic stroke.

Full Text:

PDF

References


WHO, BULL WHO, 1980:58;113-130

Goldstein LB. Evidence-based medicine and stroke. Neuroepidemiology. 1999;18(3):120-4.

Hankey GJ. Stroke: how large a public health problem and how can the neurologist help? Arch Neurol. 1999;56(6): 748-54.

Bhuwesh Agarwal, Alexandra Berger, Klaus Wolf and Friedric C.Luft. Microalbuminuria screening by reagent strip predicts cardiovascular risk in hypertension. J Hypertens1996;14:223-228

Beamer NB, Coull BM, Clark WM, Wynn M. Microalbuminuria in ischemic stroke Arch Nerol1999;56:699-702.

Turaj W, Słowik A, Wyrwicz-Petkow U, Pankiewicz J, Iskra T, Rudzińska M, Szczudlik A.. The prognostic significance of microalbuminuria in non-diabetic acute stroke patients. Med SciMonit 2001; 7(5) 989-994.

Gumbinger C, Sykora M, Diedler J, Ringleb P, Rocco A. Microalbuminuria: a potential prognostic marker for acute stroke. Nervenarzt. 2012; 83(10): 1357-60.

Das S, Yadav U, Ghosh KC, Panchadadhyayee S, Kundu SS, Ganguly PK. A clinical study of ishemic strokes with microalbuminuria for risk stratification, short-term predictive value and outcome. J Indian Med Assoc. 2012; 110(12): 908-10.

Thampy, Anupa, and Christopher C Pais. “Early Clinical Implications of Microalbuminuria in Patients with Acute Ischaemic Stroke.” Journal of clinical and diagnostic research : JCDR vol. 10,9 (2016): OC29-OC31. doi:10.7860/JCDR/2016/19690.8533

J Chowdhury, N Sultana, S Ahmed, MM Rahman, M Akter, T Rafique. Microalbuminuria as a Predictor of Short-Term Mortality in Acute Ischemic Stroke, Bangladesh J Med Biochem 2012; 5(1): 16-19.

N, Muralidhara, Ravindra Rajanna, Shivakumar Varakanahalli, & Vijay Kumar Goyal. "Prevalence of microalbuminuria in patients with non-diabetic acute ischemic stroke." International Journal of Research in Medical Sciences [Online], 3.4 (2015): 954-957. Web. 5 Jan. 2020

Vadher, Abhishek & Chaudhary, Manin& Shah, Yash & Patel, Vaibhav & Reddy, Karthik & Chapadia, Harsh. (2015). microalbuminuria as a marker of severity and prognosis in acute ischemic stroke in non-diabetic patients. European Journal of Biomedical and Pharmaceutical Sciences. 2. 678-684.

Pattanaik, S., & Dash, P. (2016). Microalbuminuria in Patients with Recent Ischaemic Cerebrovascular Stroke: A Cross Sectional Study. Journal of Advances in Medicine and Medical Research, 14(10), 1-9. https://doi.org/ 10.9734/BJMMR/2016/21351

PC Mathur, Prashant Punekar, Rajesh Muralidharan. Microalbuminuria in nondiabetic acute ischemic stroke- an Indian perspective. Ann IndAcadNeurol2005;8:237-242

Geert Sulter; Christel Steen; Jacques De Keyser .Use of the Barthel Index and Modified Rankin Scale in Acute Stroke Trials.Stroke,1999; 30: 1538-1541.

Toth P, Koller A, Pusch G et al (2011) Microalbuminuria, indicated by total versus immunoreactive urinary albumins, in acute ischemic stroke patients. J Stroke cerebrovasc Dis 20(6):510-516.


Refbacks

  • There are currently no refbacks.