GASTROPROTECTIVE AND DIGESTIVE STIMULANT ACTION OF FORMULATED ENZYME RICH SUPPLEMENT (CARMOZYME) IN ANIMALS
Abstract
Carmozyme, a natural formulated enzyme rich supplement was prepared for dyspepsia, anorexia, gastric ailments, and other GI problems. The present study was design to find out the digestive stimulant actions of Carmozyme on food propulsion, gastric functions and intestinal enzymes secretions in animals. A significant dose dependent (1ml/kg, 2 ml/kg and 3 ml/kg body weight) inhibitory effect on reducing gastric volume, acidity and ulcer index were observed in Carmozyme treated animals with compared to control animals. Carmozyme also enhances the mucin content in gastric juice. Moreover, Carmozyme produced a dose-dependent effect in reducing intestinal motility and gastric emptying time in rats. It also significantly enhanced the enzymatic activities of gastric pepsin and intestinal amylase and lipase. These findings suggest that the use of enzyme rich supplements in treating hyperacidity, indigestion and abdominal discomfort. Thus, it is concluded that Carmozyme improves digestion and reduce digestive ailments.
Keywords
Full Text:
PDFReferences
(1) Mahadeva, S.; Goh, K.L. World J Gastroenterol. 2006, 12, 2661-2666.
(2) Peery, A.F.; Dellon, E.S.; Lund, J.; Crockett, S.D.; McGowan, C.E.; Bulsiewicz, W.J. Gastroenterol. 2012, 143, 1179-1187.
(3) Anderson, P.; Dalziel, K.; Davies, E.; Fitzsimmons, D.; Hale, J.; Hughes, A.; Isaac, J.; Onishchenko, K.; Phillips, C.; Pockett, R. United Eur Gastroenterol J. 2014, 2, 544-546.
(4) Tack, J.; Bisschops, R.; Saenelli, G. Gastroenterol. 2004, 127, 1239-1255.
(5) Christopher, W.; Bridges, T.R.J.; Fedorak, R.N. Can J Gastroenterol. 2012, 26, 544-542.
(6) Kim, J.; Kim, K. H.; Lee, B. J. PLoS ONE. 2017, 8(24).
(7) Tillisch, K. Gut 2006, 55, 593-596.
(8) Wang, C.S.; Floyd, R.A.; Kloer H.U. Pancreas 1986, 1, 438-442.
(9) Valerio, D.; Martin D. L.; hanson, R. J Parenter Enteral Nutr. 1981, 5,110-114.
(10) Zimecki, M.; Kruzel, M.L. J Exp Ther Oncol. 2007, 6, 89-106.
(11) Sánchez-Rivera L. J Agricultural Food Chem. 2014, 62, 11869-11875.
(12) Sivaramakrishnan, S.; Gangadharan, D.; Nampoothiri, K.M.; Soccol, C.R.; Pandey, A. J Scientific Industrial Res. 2007, 66, 621-626.
(13) Dhital, S.; Lin, A.H.M.; Hamaker, B.R. Gidley, M.J.; Muniandy, A. PLoS ONE. 2013, 8(4).
(14) Lorkowski, G. Int J Physiol Pathophysiol Pharmacol. 2012, 4, 10-27.
(15) Lee, J.; Anderson, R. Emerg Med J. 2005, 22, 122-123.
(16) Bhati, R.; Sing, A.; Bhandari, A. J-AIM. 2012, 3, 80-84.
(17) Deng, X.K.; Yin, W., Yin, F.Z.; Zhang, X.C.J Ethnopharmacol. 2006, 106, 179-186.
(18) Eldahshan, O.A.; Abdel-Daim, M.M. Cytotechnol. 2015, 67, 831-844.
(19) Jamal, A.; Javed, K.; Aslam, M.; Jafri, M.A. J Ethnopharmacol. 2006, 103, 149-153.
(20) OECD/OCDE. No. 423 Adopted December 17, 2001.
(21) Shay, H.; Komarov, S.A.; Fels, S.E.; Meraze, D.; Grustein, M.; Siplet, H. A. Gastroenterol. 1945, 5, 43-61.
(22) Sur, T.K.; Pandit, S., Sen, S.; Bhattacharyya, D.; Debnath, P.K. Expl Ani Med Res. 2013, 3, 48-56.
(23) Pandit, S.; Sur, T.K.; Jana, U.; Bhattacharyya, D.; Debnath, P.K. Indian J Pharmacol. 2000, 32, 378-380.
(24) Dhuley, J.N. Indian J Pharmacol. 1999, 31, 128-132.
(25) Edward, W.G. Anal Biochem. 1979, 99, 183-188.
(26) Srivastava, V.; Viswanathaswamy, A.H.M.; Mohan, G. Indian J Pharmacol. 2010, 42, 185-188.
(27) Leng-Peschlow E. J Pharm Pharmacol. 1986, 38, 369-373.
(28) Droppleman, D.A. J Pharmacol Meth. 1980, 4, 227-230.
(29) Adhikari, A.; Dey, A.; Kanjilal, S.; Biswas, R.; Gandhi, D.; Mondal, K.; Bhatt, B.N.; Sur, T.K.; Mohapatra, S.; Narwaria, A.; Katiyar, C.K. Oriental Pharm Exper Med. 2018, 18, 391-401.
(30) IFCC methods. J Clin Chem Acta. 1999, 281, S5-39.
(31) Varley’s Practical Biochemistry. CBS Publication, London, 1988.
(32) Tack, J. Curr Opin Gastroenterol. 2005, 21, 454-460.
(33) Munshi, S.; Santra, R.; Nandy, M.; Bhattacharya, S.; Sur, T.K. Int J Pharmacol Res. 2016, 6, 343-348.
(34) Druce, M.; Bloom, S.R. Arch Diseases Childhood. 2006, 91, 183-187.
(35) Patel, K.; Rao, A.; Saraswati, G.; Srinivasan, K Nahrung/Food. 2002, 46, 394-398.
(36) Swami, O.C.; Shah, N.J. Int J Basic Clin Pharmacol. 2017, 6, 1035-1041.
Refbacks
- There are currently no refbacks.