COMPARISON OF EFFECTIVENESS OF INTRAVENOUS PALONOSETRON VERSUS ONDANSETRON IN PREVENTION OF POST-OPERATIVE NAUSEA AND VOMITING IN LAPAROSCOPIC SURGERIES UNDER GENERAL ANAESTHESIA: A RANDOMISED DOUBLE BLIND INTERVENTIONAL STUDY

Dr. Ravi Kumar Gupta, Dr. Ruchika Makkar, Dr. P S Lamba

Abstract


Introduction: Post-operative Nausea and Vomiting (PONV) is the most common distressing symptom following surgical procedures which can
lead to medical complications and impose economic burden on the patients with psychological effects in patients experiencing anxiety about
undergoing further surgery.
Purpose: The purpose of the study was to compare the efficacy of intravenous palonosetron versus ondansetron in preventing PONV in
laparoscopic surgeries.
Materials and Methods: A randomized,double-blind interventional study was conducted in the Department of Anaesthesiology,SMS Medical
College and Hospital,Jaipur,Rajasthan,India.100 adult patients were divided into two groups of 50 each,randomized to receive 0.075 mg of
palonosetron and 4 mg of ondansetron before induction.The occurrence of nausea, vomiting and severity of nausea according to a visual analog
scale were observed immediately after the end of surgery at 0-2hrs,2-6hrs,6-12hrs and12-24hrs.Injection metoclopramide was used as a rescue
antiemetic.Details of any adverse events were recorded.
Results: The incidence of postoperative nausea and overall PONV were lower in Group P than Group O, which was statistically significant (P <
0.05).
Conclusion: Palonosetron 0.075 mg IV produced a lower incidence of PONV compared with ondansetron 4 mg IV in patients undergoing
laparoscopic surgeries.


Keywords


Adverse events,Nausea,Rescue antiemetics,Vomiting

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