CORRELATION BETWEEN THE PREVALANCE OF LOW LEVELS OF SERUM VITAMIN D IN PATIENTS OF RHEUMATOID ARTHRITIS COMPARED TO HEALTHY CONTROLS

Dr. Abhishek, Dr. Sweta, Dr. Arohi Kumar, Dr. Debarshi Jana

Abstract


Background : To examine the potential association of vitamin D levels in development of RA and its severity, a study is being conducted to find out
vitamin D levels in patients of RA in comparison to healthy controls and to find out correlation between rheumatoid arthritis and serum vitamin D
level.
Material and Methods : This cross sectional study was conducted at Narayan Medical College, Jamuhar, Sasaram. Bihar to find out the prevalence
of vitamin D deficiency in Rheumatoid arthritis patients by analysis of serum vitamin D levels.
Results : This study was a cross sectional study, conducted at a tertiary care hospital. Fifty patients of rheumatoid arthritis diagnosed according to
the 1987 revised criteria of rheumatology were included in this study. Patients diagnosed with RA for more than a year, those having chronic renal
failure, systemic lupus erythematosus, diabetes , any systemic illness and patients on enzyme inducer drugs or on calcium and vitamin D
supplements were excluded from this study. Fifty healthy control subjects were selected from general population who were age and sex matched
and were free from any systemic illness. We have compared the serum vitamin 25 hydroxy vitamin D3 levels among rheumatoid arthritis patients
and healthy controls.
Conclusion: Patients of RA, are at higher risk of falls and fractures by virtue of age and gender. The patient group who may benefit most from
correction of vitamin D deficiency are older, post-menopausal and those with little or no sunlight exposure, non-white skin, individuals with
malabsorption.


Full Text:

PDF

References


Haugeberg G, Orstavik RE, Uhlig T et al. Bone loss in patients with rheumatoid arthritis: results from a population based cohort of 366 patients followed up for two years. Arthritis Rheum 2002;46:1720-8.

Francis RM. The vitamin D paradox. Rheumatology 2007;46:1749-50.

Hollis B Assessment and interpretation of circulating 25-Hydroxy vitamin D and 1,25-Dihydroxy vitamin D in the clinical environment. Endocrinol Metab Clin North Am. 2010;39(2): 271–287.

Sharma R, Saigal R, Goyal L et al. estimation of vitamin D levels in rheumatoid arthritis patients and its correlations with disease activity. JAPI 2014;62:18-24.

Rossini M, Bongi SM, La Montagna G et al. Vitamin D deficiency in rheumatoid arthritis. Arthritis Research & Therapy; 2010, 12:R216.

Cutolo M, Otsa K, Laas K et al. Circannual vitamin D serum levels and disease activity in rheumatoid arthritis;Northern versus Southern Europe.Clinical and Experimental Rheumatology 2006;24:702-704.

Ifigenia K, Panagiotis A, Aikaterini L et al. Vitamin D and Rheumatoid arthritis Ther Adv Endocrinol Metab. Dec 2012; 3(6): 181–187.

Allam NT, El-Wakd M, EL-Abdo DM et al. Prevalence of vitamin D deficiency in Egyptian rheumatoid arthritis patients: correlation with disease activity, functional disability, and bone mineraldensity;2014:41(3):92-97.

Juan C, Wen L, Qingyan L et al. Vitamin D deficiency and low bone mineral density in native Chinese rheumatoid arthritis patients. Rheumatology Department, The First Afflicted Hospital of Xiamen University, Xiamen, China.

Furst E, Ranganath K Chang H,et al. Clinical and Experimental Rheumatology 2009; 27: 560-566.

Hutchinson R,Davis P,Jayson M et al. Thrombocytosis in rheumatoid arthritis. Ann Rheum Dis 1976;35:138-142 doi:10.1136/ard.35.2.138. nn Rheum Dis. 1981 Dec;40(6):580-3.


Refbacks

  • There are currently no refbacks.