PARATHYROID HORMONE LEVEL IN PULMONARY TUBERCULOSIS PATIENTS

Abstract

BACKGROUND: Pulmonary tuberculosis is a deadly infectious disease caused by acid fast bacilli Mycobacterium Tuberculosis and is
responsible for more than 1.5 million deaths every year, hence is a major global health problem specially in developing countries. Interrelation
between Tuberculosis and malnutrition is as old as the disease itself. Disease outcome and morlality in PTB depends on strength of immune system
which in turn influenced by the nutrilional status of an individual. Calcium is an essential macro mineral is altered in various infection including
granulomatous diseases.
MATERIAL AND METHOD : The study was conducted on 100 adults (both males and females) from low socioeconomic status out of which 40
were newly diagnosed (Group A), 30 were relapsed PTB cases (Group B) and 30 were healthy age and gender matched non family member of
patients that served as controls (Group C). After an informed consent, all were subjected to anthropometric measurements and biochemical
investigations i.e Total protein (Biuret Method, Accurex), Albumin (BCG dye binding method Accurex). Total Calcium (Arsenozo III Methord,
Accurex), Phosphorus (Phosphomolybdate UV Method, Accurex) and ALP (Kinetic Method).
RESULT AND DISCUSSION : No significant difference was seen in ages among all the groups. BMI, Total protein and Albumin were
significantly (P<0.05) low in Pulmonary Tuberculosis (PTB) than controls. Since TB is associated with severe chachexi, wasting and low albumin,
lonic and corrected TCa was calculated and were singnificantly high (p<0.05).
CONCLUSION : Poor nutrition(Low protein)may be a risk factor for the tuberculosis. And studies indicating that incidence of tuberculosis is
unusually high among malnourished people. The host protective immune mechanism of TB infection depends critically on the interaction and
cooperation between monocyte –macrophages and t-lymphocytes .