BACTERIAL AND FUNGAL PROFILE OF CORNEAL ULCERS OF PATIENTS ATTENDING INTEGRAL INSTITUTE OF MEDICAL SCIENCES & RESEARCH(IIMS&R) LUCKNOW

Manzoor Ahmed Thokar, Talib Ansari, Rubie Malhotra

Abstract


A total of fifty corneal ulcer samples were collected & processed for bacterial & fungal study. The study showed that 80% (40 out of 50) samples
were positive for growth of either fungus or bacteria, there was no growth seen in 10 samples (healthy individuals). Among 40 positive samples, 13
(32.5%) samples showed positive bacterial isolates whereas 27 (67.5%) samples were positive for fungal keratitis. Corneal ulceration was
encountered in all age groups in this study with preponderance among 30-70 years of age group,
The prevalence was higher in males than females attributing to 60% of total samples. Male preponderance in bacterial keratitis was 53.8% whereas
in fungal keratitis came out to be 62.9% respectively. Among bacterial isolates, gram positive bacteria were more predominant than gram negative
bacteria & showing incidence of 83.6% and 23.07% respectively. The commonest bacterial isolates were Staphylococcus aureus (53.8%) and
Pseudomonas aeruginosa (23.07%). Vancomycin, teicoplanin and linezolid showed 100% sensitivity for gram positive bacterial isolates followed
by gentamycin (71%) & P. aeruginosa isolates showed 100% sensitivity with ceftazidime/clavulanic acid, cefepime, polymixin B and colistin
sulphate whereas 66.66% sensitivity was found in gentamycin and tazobactam, aztreonam, meropenem and & low sensitivity of 33.33% was seen
with piperacillin. All strains of P.aeruginosa were found resistant to levofloxacin and ciprofloxacin.
Fungal isolates of Fusarium spp. 33.33% , Aspergillus flavus 14.81% and Aspergillus niger 14.81% were grown in our study. Organic matter was
found to be most common predisposing factor in microbial keratitis & unilateral eye was mostly affected in our study.


Keywords


corneal ulcer, Keratitis, Staphylococcus aureus, Pseudomonas aeruginosa, Fusarium, Aspergillus, Antimicrobial Sensitivity

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