EFFECT OF SELENIUM SUPPLIMENTATION IN BRONCHIAL ASTHMA IN CHILDREN IN THE AGEGROUP OF 1-12 YEARS

Prashant Patil, Pushparaj Patil

Abstract


DESIGN: RANDOMISED CONTROLLED TRIAL
SETTINGS: TERTIARY CARE HOSPITAL
METHODPATIENTS:
Children of age group between 1-12 years attending OPD/IPD with symptoms of asthma, having recurrent wheeze (more than 2
episodes in 1 year) were included in study.
INTERVENTION: Patients were randomized in 2 groups i.e. cases and controls. One group (cases) has received Selenium supplementation
according to RDA for respective age of patient for duration of 6 month along with their ongoing management for asthma. Second group (controls)
received Placebo for duration of 6 month along with their ongoing management for asthma.
MAIN OUTCOME MEASURE(S): History of symptoms and treatment was documented in every 15 days interval. Anthropometric
measurements were recorded in every 3 month interval up to 6 months.
RESULTS: It was observed that there was significant improvement in grade of asthma in 9 (21.4%) patients of Se group as compared to 2 (4.8%)
patients in control group(p value=<0.05). There was significant reduction in number of wheezing episodes in Se group. 22(52.38%) patients in Se
group had less than 5 episodes in 6 month period as compared to 8(19.05%) in control group. The difference in number of hospitalizations required
in Se group was significantly less(p=<0.05) as compared to control group. There after 6 month follow up which is Statistically significant
improvement in grade of PEM was seen in Se group as compared to control group(p value <0.05).
OBJECTIVE: Primary objective was to Study Effect of selenium supplementation in bronchial asthma in children of age group 1-12 years.
Secondary objective was to study the effect of selenium supplementation on growth in asthmatic children.
CONCLUSIONS:- Selenium supplementation as per RDA is beneficial in improving symptomatology of asthma, nutritional status and hence
quality of life of asthmatic patients in pediatric age group.


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