Dr. Rahul, Dr. Jasmin Das


Introduction: Acute kidney injury (AKI) is major global public health problem. AKI is defined as a functional or structural abnormality of the
kidney as determined by blood, urine or tissue tests or by imaging studies. AKI complicates upto 30% of admissions to intensive care units (ICU).
AKI is associated with very high rates of morbidity and mortality.
Materials and Methods: This is a prospective observational cohort study conducted in department of Nephrology in Christian Medical College
and Hospital, Ludhiana over a period of one year. Patients admitted in ICU fulfilling inclusion criteria were studied for the prevalence, risk factors,
etiology, outcomes of AKI and to compare for early diagnosis of AKI using RIFLE( risk, injury, failure, loss and end stage renal disease and AKIN (
acute kidney injury network) criteria. Independent unpaired t-test , Mann-Whitney U test and Chi-Square test were used for statistical analysis.
Results: A total of 360 patients were enrolled, 65.1% were male and 34.9% were females. The prevalence of AKI in ICU was 85.5% by AKIN and
80.7% by RIFLE criteria. Sepsis was the most common cause of AKI seen in 61.8% and 63.1% of patients by AKIN and RIFLE criteria. Mortality
was 22.3% and 23.2% by AKIN and RIFLE criteria respectively. RRT was required by 29.8% and 31.4% of AKI patients diagnosed by AKIN and
RIFLE criteria. Mortality rate of patients receiving RRT was 65.5%. Hypotension resulted in AKI in 56.3% and 58.4% of patients by AKIN and
RIFLE criteria and RRT was required in 39.4% and 40.3% of these patients respectively.
Conclusion: Prevalence of AKI in ICU is high. The AKIN criteria helps in early and more diagnosis of AKI compared to RIFLE criteria.
Hypotension and sepsis were the most common causes of AKI. Mortality was higher in AKI compared to non-AKI patients.


Acute kidney injury, ICU, AKIN, RIFLE

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