ANTIBIOTIC RESISTANCE PROFILE OF CLINICALLY SIGNIFICANT BACTERIA ISOLATED FROM VARIOUS CLINICAL SPECIMENS IN A TERTIARY CARE HOSPITAL IN CHANDRAPUR

Dr. Rajendra Surpam, Dr. Ruchita Gawande, Dr. Bhausaheb Munde, Dr. Virendra Kolhe

Abstract


Our study was aimed to generate data on prevalence of antibiotic resistance among clinically significant bacteria isolated from patients at a tertiary
care hospital in Chandrapur, Maharashtra, India. Various clinical samples were processed for culture, identification and AST by conventional
method. Among 265 different isolates, 54.3% were Gram positive and 45.6% were Gram negative. The commonest pathogen isolated was
Staphylococcus aureus, followed by E.coli. Among S. aureus, 51.9% were MRSA. Most of Gram positive bacteria were resistant to co-trimaxozole
and ciprofloxacin while most Gram negative bacilli were resistant to ampicillin, amoxyclav, co-trimoxazole and cephalosporins. Least resistance
was for amikacin. The study showed a high rate of MRSA infection along with in general resistance amongst gram positive and negative isolates to
commonly used drugs underlining need of continuous surveillance, antimicrobial stewardship and strict infection control program to restrict the
ongoing resistance.


Keywords


Antibiotic resistance, bacterial pathogen, MRSA

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References


Antimicrobial resistance in India: A review J Nat SciBiol med 2013;4:286-91.

Choudhary R, Panda S, Singh DV. Emergence and dissemination of antibiotic resistance: A global problem. Indian J Med Microbiol.2012;30:384-90.

Ventola CL. The antiobiotic resistance crisis. PT. 2015;40:277–283

Ghafur A, Mathai D, Muruganathan A, Jayalal JA, Kant R, Chaudhary D. The Chennai declaration: A road map to tackle the challenge of antimicrobial resistance. Indian J c ancer2013;50:71-3.

McDonald LC. Trends in antimicrobial resistance in health care-associated pathogens and effect on treatment. Clin Infect Dis. 2006;42:65-71.

Miller LG, Perdreau-Remington F, Rieg G, MehdiS, et al. Necrotizing fasciitiscaused by community-associated methicillin resistant Staphylococcus aureus in Los Angeles. N Engl J Med. 2005;352:1445-53.

Paul R, Ray J, Sinha S, Mondal J. Antibiotic resistance pattern of bacteria isolated from various clinical specimens: an eastern Indian study. Int J Community Med Public Health 2017;4:1367-71.

Dutta S, Hassan MR, Rahman F, Jilani MS et al. Study of antimicrobial susceptibility of clinically significant microorganisms isolated from selected areas of Dhaka, Bangladesh. Bangladesh Journal of Medical Science Vol. 12 No. 01 Jan 13.

Laxminarayan R, Chaudhury RR. Antibiotic Resistance in India: Drivers and Opportunities for Action. PLoS Med. 2016;13:1001974.

Kotgire Santosh. A, Sunil Hatkar. S, Sufia Siddique, A.B. Deshmukh, et al. Bacteriological Profile and Antimicrobial Sensitivity Pattern of Clinical Isolates from Patients Attending Tertiary Care Hospital. Annals of Pathology and Laboratory Medicine, Vol. 03, No. 04, October - December 2016.

Clinical and Laboratory Standards Institute; Performance Standards for Antimicrobial Susceptibility Testing. 26th ed. CLSI Supplement M100S. Wayne, PA: Clinical and Laboratory Standards Institute; 2016.

Ramanath KV, Biswas P, Sunny R and John S: Study the antibiotic resistance pattern in a Tertiary Care Teaching Hospital. Int J Pharm Sci & Res 2019; 10(2): 819-29. doi: 10.13040/IJPSR.0975-8232.10(2).819-29.

Javeed I, Hafeez R. and M. Saeed Anwar. Antibiotic susceptibility pattern of bacterial isolates from patients admitted to a tertiary care hospital in Lahore. Biomedica Vol.27, Jan. – Jun. 2011Bio-18.Doc P. 19 – 23.

Jaya Sankarankutty, Soumya Kaup. Distribution and Antibiogram of Gram Negative Isolates from Various Clinical Samples at a Teaching Hospital, Tumkur. Sch. J. App. Med. Sci., 2014; 2(3A):927-931.

Melkamu Abebe, Senait Tadesse, Girum Meseret and Awoke Derbie. Type of bacterial isolates and antimicrobial resistance profle from diferent clinical samples at a Referral Hospital, Northwest Ethiopia: five years data analysis. BMC Res Notes (2019) 12:568.

Silpi Basak, Priyanka Singh, and Monali Rajurkar. Multidrug Resistant and Extensively Drug Resistant Bacteria: A Study. Journal of Pathogens Volume 2016, 5 pages. http://dx.doi.org/10.1155/2016/4065603.

Nazneen S, Mukta K, Santosh C, Borde A. Bacteriological trends and antibiotic susceptibility patterns of clinical isolates at Government Cancer Hospital, Marathwada. Indian J Cancer 2016;53:583-6.

Kumburu H. H., Sonda T, Mmbaga B T, Alifrangis M, et al. Patterns of infections, aetiological agents and antimicrobial resistance at a tertiary care hospital in northern Tanzania. Tropical Medicine and International Health. volume 22 no 4 pp 454–464 April 2017.

Vidya Pai, Venkatakrishna I Rao, Sunil P Rao. Prevalence and Antimicrobial Susceptibility Pattern of Methicillin-resistant Staphylococcus Aureus [MRSA] Isolates at a Tertiary Care Hospital in Mangalore, South India. Journal of Laboratory Physicians / Jul-Dec 2010 / Vol-2 / Issue-2

Mamtora D, Saseedharan S, Bhalekar P, Katakdhond S. Microbiological profile and antibiotic susceptibility pattern of Gram-positive isolates at a tertiary care hospital. J Lab Physicians 2019;11:144-8.

Mazhar Salim Al-Zoubi, Ibrahim Ali Al-Tayyar, Emad Hussein, Alla Al Jabali et al. Antimicrobial susceptibility pattern of Staphylococcus aureus isolated from clinical specimens in Northern area of Jordan. IRAN. J. MICROBIOL. Volume 7 Number 5 (Octobr 2015) 265-272.

Indian Network for Surveillance of Antimicrobial Resistance (INSAR) group, India. Methicillin resistant Staphylococcus aureus(MRSA) in India: Prevalence & susceptibility pattern. Indian J Med Res 2013;137:363 9

Praharaj I, Sujatha S, Parija SC. Phenotypic & genotypic characterization of vancomycin resistant Enterococcus isolates from clinical specimens. Indian J Med Res 2013;138:549-56.

Verghese VP, Veeraraghavan B, Jayaraman R, Varghese R, et al. Increasing incidence of penicillin- and cefotaxime-resistant Streptococcus pneumoniae causing meningitis in India: Time for revision of treatment guidelines?. Indian J Med Microbiol 2017;35:228-36

Saravanan R, Raveendaran V. Antimicrobial resistance pattern in a tertiary care hospital: An observational study. J Basic Clin Pharma 2013;4:56-63.

Hossam MA, Amany El-Sharif. Species distribution and antimicrobial susceptibility of gram-negative aerobic bacteria in hospitalized cancer patients. Journal of Translational Medicine, 2009; 7: 14.


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