Dr Koustubh R. Bagul, Dr Swayam Prava Baral, Dr Monika P. Bagul


Background: A growing body of evidence suggests that immunological and inflammatory mechanisms may play important roles in the pathophysiology of schizophrenia . Various immune alterations, such as increased frequency of activated lymphocytes, abnormal levels of inflammatory cytokines (Potvin et al. 2008, Müller 2013), and pathogenic autoantibodies (Zandi et al. 2011), have been observed in patients with schizophrenia.

 Materials and Methods: Cross-sectional study of 6 months at mgm psychiatry dept involving 100 schizophrenia patients and 100 controls after considering inclusion and exclusion criteria. Blood sample was collected for CBC parameters and ESR. PANSS and BPRS were applied.

Results: Patient group has shown significantly MORE TOTAL WBC AND POLYMORPHS than control group. POLYMORPHS COUNT has significant positive correlation with duration of illness in month.

 Haemoglobin has significant negative correlation with PANSS negative score and significant positive correlation with composite index.

Conclusion: Schizophrenia patients have raised CBC parameters as compared to healthy control and are positively correlated to duration of illness thus substantiating the inflammatory hypothesis of schizophrenia.


inflammation, immunological, schizophrenia,

Full Text:



Ayhan SS, Oztürk S, Erdem A, Ozlü MF, Ozyaar M, Erdem K, et al: Relation of neutrophil/lymphocyte ratio with the presence and severity of coronary artery ectasia. Turk Kardiyol Dern Ars 2013; 41:185-190.

Azab B, Jaglall N, Atallah JP, Lamet A, Raja-Surya V, Farah B, et al: Neutrophil-lymphocyte ratio as a predictor of adverse outcomes of acute pancreatitis. Pancreatology 2011; 11:445-452.

Miller BJ, Culpepper N, Rapaport MH. C-reactive protein levels in schizophrenia: a review and meta-analysis. Clin Schizophr Relat Psychoses 2014;7:223–30.

Müller N, Schwarz MJ: Immune System and Schizophrenia. Curr Immunol Rev 2010; 6:213-220.

Nikkilä HV, Müller K, Ahokas A, Rimón R, Andersson LC: Increased frequency of activated lymphocytes in the cerebrospinal fluid of patients with acute schizophrenia. Schizophr Res 2001: 49:99-105.

Potvin S, Stip E, Sepehry AA, Gendron A, Bah R, Kouassi E: Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol Psychiatry 2008; 63:801-808.

Rothermundt M, Arolt V, Bayer TA: Review of immunological and immunopathological findings in schizophrenia. Brain Behav Immun 2001; 15:319-339.

Semiz, M., Yildirim, O., Canan, F., Demir, S., Hasbek, E., Tuman, T. C., ... & Tosun, M. (2014). Elevated neutrophil/lymphocyte ratio in patients with schizophrenia. Psychiatria Danubina, 26(3), 0-225.

Szkandera J, Absenger G, Liegl-Atzwanger B, Pichler M, Stotz M, Samonigg H, Glehr M, et al: Elevated preoperative neutrophil/lymphocyte ratio is associated with poor prognosis in soft-tissue sarcoma patients. Br J Cancer 2013; 108:1677-1683.

Zahorec R.: Ratio of neutrophil to lymphocyte counts-- rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001; 102:5-14.

Zandi MS, Irani SR, Lang B, Waters P, Jones PB, McKenna P, et al: Disease-relevant autoan tibodies in first episode schizophrenia. J Neurol 2011; 258:686-688.


  • There are currently no refbacks.