CORRELATION OF BIOCHEMICAL PARAMETERS AND BMI WITH FRACTURES IN CHILDREN

Dr. Binoti A. Sheth, Dr. Tejas Ninawe, Dr. Pankaj Pawar

Abstract


Background : Our aim is to find out the correlation of serum levels of calcium, phosphorus and Alkaline phosphatase and Body Mass Index with
occurrence of fractures in children.
Methods : Study included total of 200 children between 2-14 years of age. Of these, 100 had sustained fractures and 100 were control samples.
Study compared four parameters i.e serum calcium, phosphorus, alkaline phosphatase and body mass index to find out whether there is any
correlation of these parameters with fractures.
Results : Higher levels of Alkaline Phosphatase were found in children with fractures and lower levels of calcium and phosphorus were found in
children with fractures than the control group. Body Mass Index of both the groups were similar.
Conclusion : Significant correlation has been found between serum levels of calcium, phosphorus and alkaline phosphatase with fractures. But, no
correlation between fractures and BMI has been found.


Keywords


Serum calcium, Phosphorus, Alkaline Phosphatase, Body Mass Index

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References


Cooper C., Dawson-Hughes B., Gordon CM., Rizzoli R. International Osteoporosis Foundation. 2015. Healthy Nutrition, Healthy Bones: How nutritional factors affect musculoskeletal health throughout life.

Cashman K. D. Diet, Nutrition and Bone Health. Journal of Nutrition. 2007:2507S–2512S. [PubMed]

O'Keefe J. H., Bergman N., Carrera-Bastos P., Fontes-Villalba M., DiNicolantonio J. J., Cordain L. Nutritional strategies for skeletal and cardiovascular health: hard bones, soft arteries, rather than vice versa. Open Heart. 2016;3(1) doi: 10.1136/openhrt-2015-000325.e000325

Weatherall M. A meta-analysis of 25 hydroxyvitamin D in older people with fracture of the proximal femur. The New Zealand Medical Journal. 2000;113:137–140.

Van der Velde R. Y., Brouwers J. R. B. J., Geusens P. P., Lems W. F., Van den Bergh J. P. W. Calcium and vitamin D supplementation: state of the art for daily practice. Food & Nutrition Research. 2014;58(1) doi: 10.3402/fnr.v58.21796

Okurowska-Zawada B1, Konstantynowicz J, Kułak W et al

Assessment of risk factors for osteoporosis and fractures in children with meningomyelocele.

Adv Med Sci. 2009;54(2):247-52. doi: 10.2478/v10039-009-0039-y.

Marcus Pauly and Reinhold Cremer

Urinary calcium excretion in children with spina bifida: correlation to level of lesion, mobility and frequency of fractures?

Cerebrospinal Fluid Res. 2009; 6(Suppl 2): S35.

Published online 2009 Nov 27. doi: 10.1186/1743-8454-6-S2-S35

Dimitri P1, Wales JK, Bishop N

J Bone Miner Res. 2010 Mar;25(3):527-36. doi: 10.1359/jbmr.090823.

Fat and bone in children: differential effects of obesity on bone size and mass according to fracture history.

Booth S. L., Broe K. E., Peterson J. W., et al. Associations between vitamin K biochemical measures and bone mineral density in men and women. The Journal of Clinical Endocrinology & Metabolism. 2004;89(10):4904–4909. doi: 10.1210/jc.2003-031673

Torbergsen A. C., Watne L. O., Wyller T. B., et al. Vitamin K1 and 25(OH)D are independently and synergistically associated with a risk for hip fracture in an elderly population: A case control study. Clinical Nutrition. 2015;34(1):101–106. doi: 10.1016/j.clnu.2014.01.016

Boonen S., Lips P., Bouillon R., Bischoff-Ferrari H. A., Vanderschueren D., Haentjens P. Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: Evidence from a comparative metaanalysis of randomized controlled trials. The Journal of Clinical Endocrinology & Metabolism.

Huang Z.-B., Wan S.-L., Lu Y.-J., Ning L., Liu C., Fan S.-W. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporosis International. 2015;26(3):1175–1186. doi: 10.1007/s00198-014-2989-6

Plaza S. M., Lamson D. W. Vitamin K2 in bone metabolism and osteoporosis. Alternative Medicine Review. 2005;10(1):24–35

Hao G., Zhang B., Gu M., et al. Vitamin K intake and the risk of fractures: A meta-analysis. Medicine (Baltimore) 2017;96(17)e6725

Roman-Garcia P., Quiros-Gonzalez I., Mottram L., et al. Vitamin B12-dependent taurine synthesis regulates growth and bone mass. The Journal of Clinical Investigation. 2014;124(7):2988–3002. doi: 10.1172/JCI72606.


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