Dr. Ramanna Macherla, Dr. Koganti Abhiram


To detect the prevalence of N34S mutation of the SPINK1 gene in alcoholic chronic pancreatitis patients and gene differs
between patients with alcoholic chronic pancreatitis. Total of 50 Alcoholic chronic pancreatitis patients was admitted In
Department of Gastroenterology, Osmania General Hospital. In the present study it was observed that 46 % patients were in the age group of 41-50
years, age range was between 33 years to 67 yrs. Further more studies are needed to be done to substantiate the results and to clarify the influence of
SPINK1 N34S on the pathogenesis and clinical course of alcoholic chronic pancreatitis. The role of genetics in Alcoholic Chronic Pancreatitis and
genotype phenotype correlations. Also, it may be useful to do functional studies of SPINK1 mutation in cell cultures to understand the
pathophysiology of disease status more completely


N34S Mutation, SPINK1 Alcoholic, Chronic Pancreatitis

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