Nitin Pandey, Sneh Jain, Praveen Kumar Baghel


INTRODUCTION: Diabetes is a chronic illness that can affect nearly every organ of body requires continuing medical care and ongoing patient self-management education and support to prevent acute complications and that will reduce the risk of long-term complications. Magnesium deficiency has recently been proposed as a novel factor implicated in the pathogenesis of diabetic complications. Recognising the signs of diabetes associated magnesium deficiency is important because the deficiency can occur long before it is reflected by serum values.OBJECTIVE:To study the serum magnesium level and establish correlation between hypomagnesemia and micro and macrovascular complications. MATERIALS AND METHODS: This cross sectional analytical study was carried out in our institution for duration of 1 year.Total of 500 subjects were enrolled in the study.Detailed clinical and laboratory investigations did for diagnosis of complications.The data was analysed using SPSS Version 16.RESULT: Prevalence of hypomagnesemia in type 2 diabetes was 33% with serum magnesium level 1.31± 0.087 mg/dl. Hypomagnesemia has significant association with microvascular complications like retinopathy(66%), nephropathy (67.54%) and neuropathy (54.5%) with p values 0.0001,0.0005,0.0001 respectively.CONCLUSION:Our study showed significant correlation between hypomagnesimia and microvascular complications of type 2 diabetes mellitus.Provided data from this study will help in management and delaying occurrence of complications, also draw attention of clinicians towards a different approach for complications.


type 2 DM,S.Magnesium level, complications.

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Alvin C. Powers,Kevin D.Niswender,Carmella Evans-Molina. chapter 396, Diabetes Melli-tus :Diagnosis,Classification,and pathophysiology In: Kasper DL, Fauci AS, Hauser SL, Lango DL, Jameson JL, Loscalzo J (eds). Harrison’s principles of internal medicine, 20th ed. New York,McGraw Hill; 2018. P. 2850 -2859.

UKPDS Group. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type II diabetes (UKPDS 33). Lancet.1998;352(9131):837-853. Erratum in: Lancet. 1999;354(9178):602.

Sanjuliani AF, De abreu fagundes VG, Francischetti EA. Effects of magnesium on blood pressure and intracellular ion levels of Brazilian hypertensive patients. Int J Cardiol. 1996;56(2):177-83.PMID:8894790

Ma J, Folsom AR, Melnick SL, Eckfeldt JH, Sharrett AR, Nabulsi AA, et al. Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: the ARIC study. Atherosclerosis Risk in Communities Study. J Clin Epidemiol. 1995 Jul;48(7):927- 40.

Sanjuliani AF, De abreu fagundes VG, Francischetti EA. Effects of magnesium on blood pressure and intracellular ion levels of Brazilian hypertensive patients. Int J Cardiol. 1996;56(2):177-83.PMID:8894790

American Diabetes Association: Diabetes Care 40(Suppl 1): S13, 2018.

Fujii S, Takemura T, Wada M, Akai T, Okuda K. Magnesium levels in plasma erythrocytes and urine in patients with diabetes mellitus. Horm Metab Res 1982;14:61-2.

Dasgupta A, Sarma D, Saikia UK. Hypomagnesemia in type 2 diabetes mellitus. Indian J Endocrinol Metab. 2012;16(6):1000-3.DOI:+10.4103/2230-8210.103020

Corsonello A, Ientile R, Buemi M, Cucinotta D, Mauro VN, Macaione S, et al. Serum ion-ized magnesium levels in type 2 diabetic patients with microalbuminuria or clinical pro-teinuria. Am J Nephrol. 2000 May-Jun;20(3):187- 92.DOI:10.1159/000013582

Prabhu G, Raadha AM, Balasubramaniyan S. A study of serum magnesium level in type 2 diabetes mellitus and its significance. Int J Med Res Rev 2015;3(7):675-681.

De Leeuw I, Engelen W, De Block C, Van Gaal L. Long term magnesium supplementation influences favourably the natural evaluation of neuropathy in mg depleted type 1 diabetic patients Magnes res.2004;17: 109 - 114.PMID: 15319143

Maria de lourdes lima TC, Judith Carreiro Pousada, Luiz Erlon Rodrigues, Karyne Barbosa, Valquiria Cangucu. The Effect of Magnesium Supplementation in Increasing Doses on the Control of Type 2 Diabetes. Diabetes Care. 1998;21(5):682- 6.

Chiristhudhas A, Devadhas AD, Dinesh S, et al. A study on correlation of serum magnesi-um in diabetic patients with proteinuria. J. Evid. Based Med. Healthc. 2016; 3(104), 5729-5733. DOI: 10.18410/jebmh/2016/1183

Guerrero-romero F, Rodríguez-morán M. Hypomagnesemia, oxidative stress, inflammation, and metabolic syndrome. Diabetes Metab Res Rev. 2006;22(6):471-6.DOI:10.1002/dmrr.644

Arpaci D, Tocoglu AG, Ergenc H, Korkmaz S, Ucar A, Tamer A. Associations of serum Magnesium levels with diabetes mellitus and diabetic complications. Hippokratia. 2015;19(2):153-7.


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