Dr. Lahari. N


Posterior Reversible Encephalopathy Syndrome also known as
Reversible posterior leukoencephalopathy. Incidence of PRES is 4-7%
in all pregnancies. PRES presents with rapid onset of symptoms
including headache, seizures, altered consciousness, and visual
disturbances. It is often, but by no means always associated with acute
hypertension. If promptly recognized and treated, the clinical
syndrome usually resolves within a week and the changes seen in
magnetic resonance imaging (MRI) resolve over days to weeks (1,2,3).
Chronic kidney disease and acute kidney injury are both commonly
present in patients with PRES, and PRES is strongly associated with
conditions that co-exist in patients with renal disease, such as
hypertension, vascular and autoimmune diseases, exposure to
immunosuppressive drugs, and organ transplantation. It is therefore
important to consider PRES in the differential diagnosis of patients
with renal disease and rapidly progressive neurologic symptoms(4).
Posterior reversible encephalopathy syndrome is an increasingly
recognized disorder, with a wide clinical spectrum of both symptoms
and triggers, and yet it remains poorly understood.

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McKinney AM, Short J, Truwit CL, McKinney ZJ, Kozak OS, SantaCruz KS, et al. Posterior reversible encephalopathy syndrome: incidence of atypical regions of involvement and imaging findings. AJR Am J Roentgenol 2007; 189:904–12 [PubMed] [Google Scholar]

Roth C, Ferbert A. The posterior reversible encephalopathy syndrome: what’s certain, what’s new? Pract Neurol 2011; 11:136–44 [PubMed] [Google Scholar]

Hinchey J, Chaves C, Appignani B, Breen J, Pao L, Wang A, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med 1996; 334:494–500 [PubMed] [Google Scholar]

Fugate JE, Claassen DO, Cloft HJ, Kallmes DF, Kozak OS, Rabinstein AA. Posterior reversible encephalopathy syndrome: associated clinical and radiologic findings. Mayo Clin Proc 2010; 85:427–32[PMC free article] [PubMed] [Google Scholar]

Hypertensive disorders of pregnancy. In: Cunningham FG, Gant NF, Leveno KJ, eds. Williams Obstetrics. 21st ed. New York: McGraw Hill;2001 :567–618

Dekker GA, Sibai BM. Etiology and pathogenesis of preeclampsia: current concepts. Am J Obstet Gynecol 1998;179:1359–75

Fischer M, Schumutzhard E. Posterior reversible encephalopathy syndrome. J Neurol 2017; 264: 1432-1459.

Hinchey J, Chaves C, Appignani B, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med 1996; 334: 494 – 500.


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