Dr. Gazala Gul, Dr. Krishanaraj Upadhyaya, Dr. Saba Bashir


INTRODUCTION: The Colonic lesions often require colonoscopic biopsy for their conclusive diagnosis. The biopsy may provide the information required to establish perfect diagnosis of the main responsible cause of lesion.  HPE of colonic mucosal biopsies when correlated with clinical findings help in definite diagnosis and early treatment of patients with colonic lesions.

METHODS: colonoscopic biopsies received by Department of Pathology from January 2017 to December, 2017.

RESULTS: A total of 150 colonoscopic biopsies were analyzed, which included 84 males and 66 females. There were 103 (68.66%) cases of      non-neoplastic lesions, 42 (28%) cases of neoplastic lesions and 5 (3.33%) cases of inadequate biopsies. Among 103 cases of non-neoplastic lesions, 46 (44%) were non-specific colitis, 10 (10%) ulcerative colitis, 5(5%) non-specific proctitis,8 (8%), inflammatory polyp, 4 (4%), hyperplastic polyp, 5 (5%), hirschprung’s disease, 4 (4%) rectal ulcer, 1 (1%) tuberculosis and 20 (19%) of non- significant pathology.

Out of 42 cases of neoplastic lesions, 25 (59.25%) were adenocarcinoma, 2 (4.76%), mucin secreting were adenocarcinoma, 2 (4.76%), signet ring cell and 13 (30.95%) were colonic adenoma.

CONCLUSION: Colonic mucosal biopsies play a crucial role in specific diagnosis of patients with inflammatory bowel disease and early detection of colonic tumors. This study emphasizes that non-specific colitis is more common among non-neoplastic lesions.


Colitis, Adenoma and Adenocarcinoma

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