Dr. Arun Kumar T, Dr. Pooja Pradeep, Dr. Sundari S


Objectives: To compare between C-reactive protein (CRP) and Procalcitonin (PCT) regarding diagnosis and outcome of neonatal sepsis.

Design: Prospective observational study.

Setting: Neonatal Intensive Care Unit (NICU).

Participants: Seventy newborn Infants admitted to NICU for sepsis management.

Results: Of the total 70 Neonates admitted in NICU, 32.9%, 41.4% and 25.7% were categorized as proven sepsis, suspected sepsis and clinical sepsis respectively. Procalcitonin was positive in 100% compared to the CRP positivity in 63.6% of the proven sepsis cases. Mortality rate is significantly increased in proven sepsis compared to clinical sepsis.

Intervention: Sepsis workup laboratory tests.

Main Outcome Measures: Specific diagnostic and prognostic impact of the tests.

Conclusion: Comparing with CRP, PCT is not only a good diagnostic measure of neonatal sepsis but also effective predictor of sepsis outcome


Procalcitonin; CRP; Neonatal; Sepsis; UTI

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