Dr. Rajendra Triloki, Dr. Shefali Mehta, Dr. Akhlaq Hassan, Dr Hemant Dashora, Dr. Shuchi Goyal


Background: Tobacco smoking is  one of the most common habit in humans across  the world which  have  many  oxidative substances  that  alteres  uric acid which is  an important antioxidant   in our body.

Aims and objectives: Study to prevent smoking as a habit and its hazards  and compare the uric acid  levels in smokers and nonsmokers with correlation with severity and duration of smoking.

Material and methods: A cross sectional study was conducted in 50 smokers and 50 nonsmokers’ healthy adults aged 18 to 45 years, both sex male or female. Samples were collected for estimation of serum uric acid level using RXL max Siemens fully auto analyzer. Data collected was analyzed using SPSS.

Results: The mean of serum uric acid level stastically significant lower in (3.59±0.88) smokers than   (4.93±1.2) nonsmoker’s (P<0.05) which inversely correlates with Numbers of cigarettes/beedis smoked and duration of smoking.

Conclusion: It was concluded that tobacco smoking lowers the serum uric acid level & significant negative  correlation  with severity of smoking and duration of smoking  leads to  compromised antioxidant level and hazards to health. 


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smoking a single cigarette rapidly reduces combined concentrations of nitrate and nitrite and concentrations of antioxidants in plasma . circulations 2002;105:1155-1157

Karnath B. smoking cessation. Am j Med 2002; 112:399-405.

Node K,Kitakaze M,Yoshikawa H, Kosaka H, Hori M. Reverse reduction in plasma concentration of nitric oxide induced by cigarette smoking in young adults. Am J cardiol 1997;79:1538-1541

Warning SW,McKnight JA, WebbDJ, Maxwell SRJ. Uric acid restores endothelial functions in patients with type 1diabetes and regulars smokers’ diabetes 2006; 55:3127-3132.

Polidori MC, Mecocci P, Stahl W, Sies H .Cigarette smoking cessations increases plasma levels of several antioxidant micronutrients and improves resistances towards oxidative challenge .Br j Clin Nutr 2003 Jul ;90(1):147-50.

Bruno RS , Ramkrishnan R, Montine TJ,Bray TM,Traber MG.alpha tocopherol disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status .Am J Clin Nutr 2005 jan ;81(1):95-103.

Mathru M, Dries DJ, Barnes L, Tonino P, Sukhani R, Rooney MW. Tourquer- induced xsanguinations in patients required lower limb surgery: an ischemia –reperfusion model of oxidant and antioxidant metabolism .anesthesiology 1996; 84:14-22.

Hellsten Y, Tullson PC, Richer EA, Bangsbo J. oxidation of urate in human skeleton muscle during exercise . Free Radiac Boil Med1997; 22:169-174.

Peto J. That the effects of smoking should be measured in pack-years: misconceptions. British Journal of Cancer 2012; 107(3): 406-407.

Kawachi, Ichiro, and Graham A. Colditz. Workplace exposure to passive smoking and risk of cardiovascular disease: summary of epidemiologic studies. Environmental Health Perspectives 1999; 107(Suppl 6): 847-851.

Wu J, Sin DD. Improved patient outcome with smoking cessation: when is it too late? International Journal of Chronic Obstructive Pulmonary Disease. 2011;6: 259-267.

Tahani Majzoub Ali et al, NMJ November 2013 volume3 no.12 ISSN 1858-627


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