Mudasir Ahmad Wani, Dr Vinita Ailani, Dr Shikha Saxena


Background: Obesity is associated with adverse cardiovascular events which could be due to the altered autonomic balance seen in these individuals. Nowadays obesity is recognized as a major, worldwide, health problem.

Material and Method: The present study was conducted in the Department of Physiology, at National Institute of Medical Sciences and Research, Jaipur. 50 obese (25 male and 25 female) and 50 non obese (25 male and 25 female) were included. Parasympathetic tests were performed on both groups. All data are expressed as mean± standard deviation. Comparison between groups obese male, non obese male, obese female and non obese female was performed using the student’s t-test (t-test for two independent samples / Two-tailed test). Differences was considered significance at p<0.05.  

Result: It was observed that young obese adults had reduced parasympathetic activity.

Conclusion: This altered balance of the autonomic nervous system increases the risk of cardiovascular disorders.


Cardiovascular diseases and obesity, Obesity, Parasympathetic system and obesity

Full Text:



Harrison’s Principles of Internal Medicine: Text book of Medicine. 18ed; MeGraw Hill.1619

World Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO consultation presented at: the World Health Organization; June 3-5, 1997; Geneva, Switzerland. Publication WHO/NUT/NCD/98.1

Samuel K, Lora E B, George A B, Steven B, David B A, Xavier P S, Yuling H, Robert H E: Clinical implications of obesity with specific focus on cardiovascular disease: A statement for professionals from the American Heart Association council on Nutrition, Physical activity and Metabolism. Circulation. 2004; 110: 2952-2967.

Kirsten LR, Harry H, Meena K, Eric B, Marek M, Michael M. Effects of moderate and vigorous physical activity on heart rate variability in British study of civil servants. Am J Epidemiol. 2003; 158: 135-43.

Frenco R, Bernard S, Andrea C, Tiziana G, Barbara D V, Ivana R: Assessment of cardiac autonomic modulation during adolescent obesity. Obes Res. 2003 April: 11(4): 541-548.

Zipes D P, Wellens H J J: Sudden Cardiac Death. Circulation. 1998; 98: 2334-51.

Vanoli E, Schwartz P J: Sympathetic – Parasympathetic interaction and sudden death. Basic Res Cardiol. 1990; 85 suppl 1: 305-21.

Masuo K, Mikami H, Ogihara T, Tuck M L: Weight gain-induced blood pressure elevation. Hypertension. 2000; 35: 1135-40.

Angelone A, Coulter NA. Respiratory sinus arrthymia: a frequent dependent phenomenon. J Appl Physiol. 1964;19:479-482.

Baum P et al, 2013. Dysfunction of autonomic nervous system in childhood obesity: a cross-sectional study. PloS One. 2013; 8(1):e54546

Chetan et al, 2012 Chethan HA, Niranjan Murthy, Basavaraju K. Comparative study of heart rate variability in normal and obese young adult males. Int J Biol Med Res. 2012; 3(2): 1621-23

Emdin M et al, 2001 Emdin M, Gastaldelli A, Muscelli E, Macerata A, Natali A, Camastra S, Ferrannini E: Hyperinsulinemia and autonomic nervous system dysfunction in obesity: Effect of weight loss. Circulation. 2001; 103: 513-19.

Borne 1999. Bedi M, Khullar S, Varshney VP. Assessment of autonomic function activity in obese children. Vascular Disease Prevention. 2009; 6: 139-141.

Garg R et al. 2013. A study of autonomic function tests in obese people. Int J Med Res Health Sci. 2013;2(4):750-755

Kimura T, Matsumoto T, Akiyoshi M, Owa Y, Miyasaka N, Aso T, et al. Body fat and blood lipids in postmenopausal women are related to resting autonomic nervous system activity. Eur J Appl Physiol. 2006;97:542–7


  • There are currently no refbacks.