Senthamizhselvan K, Mohammed A


Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare entity in clinical practise. It can occur in the setting
of infection, malignancy, autoimmune disease and immunodeficiency.
Case report: We present a case of 18 years old male who had fever, rapid weight loss and upper gastrointestinal bleeding during the past 1 month.
Gastroscopy showed an ulcerated lesion in stomach, histopathology and immunohistochemistry was suggestive of gastric T-cell lymphoma
(NHL). Patient had persistent fever and drop in cell counts of all 3 lineages. Bone marrow examination revealed hemophagocytosis secondary to
gastric T-cell NHL. His general condition worsened rapidly and he succumbed to his illness, before any definitive therapy could be initiated.
Conclusion: One should have a high index of suspicion to diagnose HLH, so as to initiate early treatment and improve survival.


Hemophagocytic lymphohistiocytosis, Lymphoma, Ulcer, Gastroscopy

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