INCIDENCE OF MICRONUCLEI IN BUCCAL EPITHELIAL CELLS OF COAL MINERS

K Rudrama devi, Minny Jael. P

Abstract


Coal is known carcinogen. Workers employed in coal industry are exposed to larger amounts of cement dust particulates in work place results to harmful health effects. In the present study assessment of genetic damage was evaluated using micronucleus assay in coal industry workers buccal epithelial cells.  A total of 80 subjects were selected from Singareni collaries kothagudem, Telangana, India and 60 individuals were served as controls having same diet, social economic   background. The buccals were collected from oral cavity and analysed for nuclear abnormalities. A high frequency of karyolysis was noted in exposed group with longe duration of exposure. A significant increase in the frequency of micronucleus was observed in exposed group when compared with control data. A synergistic effect was observed in smokers exposed group.  Thus the data clearly indicate the effect of  coal dust  in coal industry workers,  the present studies indicate the  use of micronucleus  assay to identify the the groups that are risk for developing   cancer.

Keywords


Coal, micronuclei, buccal cells

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