COMPARISON OF TWO FRACTIONATION SCHEDULES IN TERMS OF LOCO REGIONAL CONTROL AND TOXICITY PROFILE IN POSTMASTECTOMY RADIOTHERAPY

Dr. L. Karpagavalli, Dr. P. Vidya

Abstract


In a general radiation oncology practice, breast cancer typically constitutes approximately 25% of total patient caseload. Radiation therapy (RT) plays an essential and critical role in the management of breast cancer. Locally advanced breast cancer is not clearly defined, though it commonly refers to stage III disease, which includes advanced primary or nodal disease without evidence of systemic metastases. Patients who present with locally advanced breast cancer require care from a multidisciplinary team.The purpose of this study was to compare two fractionation schedules(50Gy in 25 fractions vs 40Gy in 15 fractions) used in post mastectomy chest wall irradiation in Carcinoma Breast regarding loco-regional control and toxicity profile. Several studies have shown that two fractionation schedules are equivalent in loco-regional control and cosmetic outcome.The composition of this study is well matched regarding age, surgery and other histopathological findings.

 


Keywords


Breast cancer, Hypo fractionation, Toxicity, Survival.

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References


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