LOW DOSE 10 GRAM INTRA MUSCULAR VERSUS CONVENTIONAL DOSE OF MAGNESIUM SULPHATE FOR ECLAMPSIA PROPHYLAXIS

Dr. Nirmala Sharma, Dr. Neha Seehra

Abstract


Optimum dose, route and duration of magnesium sulfate prophylaxis has always been debatable in HDP .Our objective is to reduce the eclampsia incidence while dealing with low dose ,we compared the efficacy of 10 gram I.M. MgSO4 loading dose only versus conventional dose for seizure prophylaxis over 100 women . With mean age  of 24.83 years , 58%  being primigravida, none of the patients in both groups developed eclamptic seizures, atonic pph  and oliguria was significantly low in low dose group with a p value <0.05 , no maternal mortality observed in both the  groups . Neonatal outcomes were statistically insignificant . low dose 10 gram I.M. loading dose only may be considered as an effective alternative for eclampsia prophylaxis , for its potential use in low resource peripheral health centres. With minimal monitoring it can help to reduce maternal morbidity, mortality and improved neonatal outcome .


Keywords


Severe pre eclampsia , Hypertensive disorders of pregnancy (HDP) , Magnesium sulphate(MgSO4) .

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References


f. gary Cunningham ., Kenneth j. leveno , steven L bloom (2018) hypertensive disorders , Williams obstetrics (25th edition), McGraw-Hill Education .

Dr lale say,MD, Doris Chou,MD, et al , (2014) , Global cause of maternal death: a WHO systematic analysis ,The Lancet Global Health, vol.2 issue 6 , PE323-E333.

Bhawna malhotra singh ,renu mishra , (2014). Hypertensive disorders , Ian Donald’s practical obstetrics problem(7th ed.) .New Delhi wolters kluwer India.

The Magpie trial Collaborative group.

( 2002). Do women with pre eclampsia and their babies benefit from magnesium sulphate ? The magpie trial: a randomised controlled trial, Lancet;359:1877

Bembalgi S et al , int j reprod , contracept (2016), Use of single dose prophylactic magnesium sulphate in severe pre eclampsia in preventing seizures. Obstet gynecol ;5(7): 2261-2263

Keepanasseril A et al (2018) prophylactic magnesium sulfate in prevention of eclampsia in women with severe pre eclampsia: randomized controlled trial (PIPES trial) , j obstet gynecol; 38(3) :305-309.

Darngwan L et al ,( 2012) A shortened postpartum prophylaxis regime in pre eclamptic women at low risk of eclampsia, international journal of obstetrics and gynecology , vol. 116 , issue3 , page no. 237-239

Surya Prasad et al, (2017) loading dose only versus standard dose magnesium sulfate seizure prophylaxis in severe pre eclamptic women . j Nepal med assoc ; 56 (208) : 388-94

Begum R , Begum A , johanson R , Ali MN , Akhter S. (2001) A low dose(“Dhaka”) magnesium sulphate regime for eclampsia. Acta obster gynecol Scand ;80(11) ;998-1002.

Suman S, shinanjalin M, ajit P , uday P. (2003) low dose magnesium sulphate therapy for eclampsia and imminent eclampsia: regimen tailored for indian women. J obstet gynecol Indi. ;55:546-50 .

Miriam Geroge Fenn , Padmini jasper , (2014) “ A double blind randomized clinical trial comparing pritchard’s regimen with low dose in women with severe pre eclampsia and eclampsia” journal of evolution of medical and dental sciences ; vol 3, issue 46, sept.22 ; page 1175-1185 .


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