STUDY OF LIPID PROFILE ABNORMALITIES IN CORRELATION WITH SONOLOGICAL GRADING OF NAFLD.

Prathyusha Thummalagunta, B MadhuKiran Reddy, Dinesh Reddy Polareddy, Shaik Shazia Amrin

Abstract


Background: NAFLD is a significant cause of chronic liver disease and is now regarded as the hepatic manifestation of the metabolic syndrome. The morbidity and mortality related to NAFLD is expected to rise with the upsurge of obesity and type 2 diabetes mellitus. It encompasses a wide spectrum that ranges from fat accumulation in hepatocytes to hepatic steatosis with inflammatory component that may or may not have associated fibrosis. The aim of the present study is to investigate the association of lipid profile abnormalities in patients with different grades of fatty liver.

Methods: A total of 100 cases diagnosed with NAFLD on ultrasound were divided  in to 3 groups based on sonological grading. They were further divided based on age into five groups. of which 55 are males, and 45 are females. All patients were subjected to complete history taking and clinical examination, fasting lipid profile, routine laboratory investigations, thyroid profile.

Results:  in this study of 100 patients, 52 % are grade I, 30 % are grade II, and 18 % are grade III NAFLD. Serum TG, TC, LDL-C, and HDL-C levels were abnormally raised in 57%, 55%, 60%, and 59% patients, respectively. Thirty-three cases are diabetic, eight individuals consume alcohol, and Thirty individuals are overweight in the present study population.  

Conclusions: The sonological grade of the Fatty liver correlate with the biochemical lipid abnormalities i.e., with higher the grade of fatty liver more is dyslipidemia.


Keywords


Non-alcoholic fatty liver disease (NAFLD), chronic liver disease, metabolic syndrome

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References


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