Shiva Shankara A. R., Manjeshwar Shrinath Baliga, Princy L. Palatty


Sandalwood has many benecial effects on health. The anticancer and skin protective effects of sandalwood have been
proposed to be due to its anti-inammatory, antioxidant, antimicrobial and antiprotease effects . The present study aimed
to assess the antielastase and antihyaluronidase effects of sandalwood. Aqueous extract of sandalwood (50 mg/ml) was added to the reaction
mixtures of elastase and hyaluronidase enzyme assays to test its inhibitory effect. This in vitro study demonstrated that sandalwood extract
inhibited elastase acitivity and hyaluronidase activity by 81% and 72% respectively. Applying aqueous extract of sandalwood after grinding it
against a stone with water, is a common practice in India. This religious practice has to be seen from scientic perspective of skin protecting effects
of sandalwood.

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Kumar ANA, Joshi G and Ram HYM: Sandalwood: history, uses, present status and the future. Current Science 103: 1408- 1416, 2012.

Santha S, Dwivedi C. Anticancer effects of sandalwood (Santalum album). Anticancer Res 2015; 35: 3137-3146.

de veer SJ, Furio L, Harris JM, Hovnania A. Proteases: culprits in human skin disorders. Trends Mol Med 2014; 20: 166-178.

Thring TSA, Hili P, Naughton DP. Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants. BMC Complementary and Alternative Medicine 2009; 9: 27. doi:10.1186/1472-6882-9-27

Kaur M, Agarwal C, Singh RP, Guan X, Dwivedi C, Agarwal R. Skin cancer chemopreventive agent, a-santalol, induces apoptotic death of human epidermoid carcinoma A431 cells via caspase activation together with dissipation of mitochondrial membrane potential and cytochrome c releaseCarcinogenesis 2005; 26: 369-380.

Sunitha K, Suresh P, Santhosh MS, Hemshekhar M, Thushara RM, Marathe GK, et al. Inhibition of hyaluronidase by N-acetyl cysteine and glutathione : role of thiol group in hyaluronan protection. Int J Biol Macromol 2013; 55: 39-46.

Girish KS, Kemparaju K, Nagaraju S, Vishwanath BS. Hyaluronidase inhibitors : a biological and therapeutic perspective . Curr Med Chem 2009; 16: 2261-2288.

Mori M, Ikeda N, Kato Y, Minamino M, Watabe K. (2002) Inhibition of elastase activity by essential oils in vitro. Journal of Cosmetic Dermatology, 1, 183-187.

Yahaya YA, Don MM. Evaluation of trametes lactinea extracts on the inhibition of hyaluronidase, lipoxygenase and xanthine oxidase activities in vitro. J Phys Sci 2012;23:1–15

Moy RL, Levenson C. Sandalwood album oil as a botanical therapeutic in dermatology. J Clin Aesthet Dermatol 2017; 10:34-39.

Bommareddy A, Knapp K, Nemeth A, Steogerwalt J, Landis T, Vanwert AL, et al. Alpha-santalol, a component of sandalwood oil inhibits migration of breast cancer cells by targeting the β-catechin pathway. Anticancer Res 2018; 38: 4475-4480.


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