Dr. Jyothi Vybhavi V. S.


Ageing is a natural process and healthy ageing has become a growing global challenge. The process of ageing affects
nutritional needs, they are particularly prone to inadequate intake of calcium and vitamin D. Vitamin D deciency is
widely prevalent across all ages, races, geographical regions, and socioeconomic strata. Vitamin D deciency has been linked to cardiovascular
disease and risk factors including hypertension. The relationship between Vitamin D and Hypertension has varied across studies; hence this study
was taken up to evaluate the relationship between hypertension and Vitamin D levels in the senior citizens of Bangalore City. The objective of this
study is to assess Serum 25(OH) Vitamin-D, and Blood Pressure in senior citizens of Bangalore city, and to evaluate the interrelationship of the
above parameters in the same subjects. As part of the methodology, after obtaining Ethical Clearance, 80 eligible elderly subjects were recruited
for the study. Written informed consent was taken. For each subject, fasting blood sample of 4ml was collected for Serum 25(OH) Vitamin-D
assessment. Height and weight were measured, and Blood pressure was measured, and Hypertension was diagnosed based on JNC VII criteria.
Results were compiled and statistically analyzed. The analysis showed that severe vitamin D deciency was present in subjects with
hypertension than in people without hypertension (P value <0.05). To conclude, this study demonstrates increased rates of hypertension in
individuals who tested for lower levels of 25-hydroxyvitamin D starting at levels < 20 ng/ml. Elevated Blood Pressure levels associated with
Vitamin-D deciency in the elderly warrants a need for clinical monitoring and appropriate intervention.


Hypertension, Vitamin D, Blood pressure

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Jeyalakshmi S, Chakrabarti S, Gupta N. Situation Analysis of The Elderly in India. New Delhi : Central Statistic s office ,Ministry of statistics & Programme Implementation. Government of India; 2012

United Nations Population Fund. Elderly to constitute 20 percent of India’s population by 2050: Report. New Delhi; 2012

Caruso LB,Silliman RA. Harrison's Principles of Internal medicine. 17th ed. USA:McGraw Hill;2008.p. 53-62.

Todkar SS, Gujarathi VV, Tapare VS. Period prevalence and sociodemographic factors of hypertension in rural Maharashtra: A cross-sectional study. Indian J Community Med 2009;34(3):183-7.

Gupta R, Gupta VP, Sarna M, Bhatnagar S, Thanvi J, Sharma V et al. Prevalence of coronary heart disease and risk factors in an urban Indian population: Jaipur heart watch 2. Indian Heart J 2002;54(1):59-66.

World Health Organization. Integrated management of cardiovascular risk, report of a WHO meeting. Geneva; WHO:2002.p.5-9. 4. Birkenhager WH, F

Holick MF. Vitamin D deficiency. N Engl J Med. 2007; 357( 3): 266– 281

Vasan RS, Larson MG, Leip EP, et al. Impact of high‐normal blood pressure on the risk of cardiovascular disease. N Engl J Med. 2001; 345( 18): 1291– 1297

Zittermann A. Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol. 2006; 92( 1): 39– 48.

Somjen D, Weisman Y, Kohen F, et al. 25‐hydroxyvitamin D3‐1alpha‐hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds. Circulation. 2005; 111( 13): 1666– 1671.

Kristal‐Boneh E, Froom P, Harari G, et al. Association of calcitriol and blood pressure in normotensive men. Hypertension. 1997; 30( 5): 1289– 1294.

McCarty MF, Thomas CA. PTH excess may promote weight gain by impeding catecholamine‐induced lipolysis‐implications for the impact of calcium, vitamin D, and alcohol on body weight. Med Hypotheses. 2003; 61( 5–6): 535– 542.

Rostand SG. Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension. 1997; 30( 2 Pt 1): 150– 156.

Schedl HP, Miller DL, Pape JM, et al. Calcium and sodium transport and vitamin D metabolism in the spontaneously hypertensive rat. J Clin Invest. 1984; 73( 4): 980– 986.

Li YC, Kong J, Wei M, et al. 1,25‐Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin‐angiotensin system. J Clin Invest. 2002; 110( 2): 229– 238.

Chobanion AV, Bakris GL, Black HR. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure- The JNC 7 report. JAMA 2003;289:2560-72.

Norman AW, Bouillon R. Vitamin D nutritional policy needs a vision for the future. Exp Biol Med. 2010;235:1034–45.

Fradinger EE, Zanchetta JR.Vitamin D and bone mineral density in ambulatory women living in Buenos Aires, Argentina. Osteoporosis Int. 2001;12:24-7.

Holick MF Siris E, Binkley N. Prevalence of Vitaamin D inadequacy among postmenopausal North American women recieving osteoporosis therapy. J Clin Endocrinol metab. 2005;90:3215-24.

Holick MF. The Vitamin D deficiency pandemic: a forgotten hormone. Public health reviews. 2010;32:267-83. 16. Holick MF.. Vitamin D : Adelightful solution for health. J Investig Med. 2011;59(6):872-80

Maclaughlin J A, Holick M F. Aging decreases the capacity of human skin to produce Vitamin D3. Journal of clinical investigation. 1985;76:1536-8.

Omdahl JL. Nutritional status in a healthy elderly population:Vitamin D. The American journal of clinical nutrition. 1982;36:1225-33. 16. Munger KL, Levin LI, Hollis BW, Howard NS,

Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. American journal of hypertension. 2007;20:713–9

Bhandari SK, Pashayan S, Liu IL, Rasgon SA, Kujubu DA, Tom TY, et al. 25-hydroxyvitamin D levels and hypertension rates. Journal of clinical hypertension. 2011;13:170–7.

Forrest KY, Stuhldreher WL. Prevalence and correlates of vitamin D deficiency in US adults. Nutrition research. 2011;31:48–54

Martins D, Wolf M, Pan D, Zadshir A, Tareen N, Thadhani R, et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Archives of internal medicine. 2007;167:1159–65

Li YC, Qiao G, Uskokovic M, Xiang W, Zheng W, Kong J. Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure. Journal of Steroid Biochemistry and Molecular Biology. 2004;89-90:387–392.

Kong J, Qiao G, Zhang Z, Liu SQ, Li YC. Targeted vitamin D receptor expression in juxtaglomerular cells suppresses renin expression independent of parathyroid hormone and calcium. Kidney International. 2008;74(12):1577–1581


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