ROLE OF ADIPONECTIN, INTERLEUKIN-6 AND SOMATIC DNA DAMAGES FOR PREDICTING CARDIOVASCULAR DISEASES AMONG SUBJECTS WITH PREHYPERTENSION

Anaswara A A, Sharmila K, Aishwaria J, Viji Krishnan, Dinesh Roy D

Abstract


Prehypertension is one of the important potential candidates and independent predictor for both cardiovascular and
cerebrovascular diseases. Newer biomarkers for the early diagnosis and prediction for cardiometabolic syndrome and
CVD events among prehypertension is essential. The aim of the present study is to assess the role of Adiponectin and Interleukin-6 (IL-6) among
prehypertensive subjects and to correlate with the various risk factor associate with Cardiometabolic Syndrome in prehypertensive subjects. A
case-control study was conducted. The study group included 157 clinically diagnosed prehypertentsive subjects and 100 age and sex matched
healthy control subjects. Adiponectin and Interleukin-6 (IL-6) had a signicant role in association with somatic DNA damage in prehypertensive
subjects and its earlier prediction of CMS. The increased mean CBMN frequency among the study subjects with 95% of condence interval
revealed its predictability for CMS. Adiponectin and interleukin-6 were also proved its strong predictability for CMS. Overall, this study recorded
wider understanding of biochemical and molecular events in prehypertensive subjects which leads to high risk for CVD.


Keywords


Prehypertension, cardiovascular diseases, Cardiometabolic Syndrome, CBMN Assay, Adiponectin and Interleukin-6

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