COMPARISON BETWEEN TWO COMMONLY USED EMPERIC ANTIBIOTOC REGIMENS IN NEONATAL SEPSIS

Sheikh Quyoom Hussain, Juvera Gul Wani, Roshi Baghat

Abstract


Background: Neonatal sepsis remains a major cause of morbidity and mortality and warrants the immediate start of appropriate empiric treatment. Thus, this study compared the effectiveness of the 2 antibiotic regimens (cloxacillin–amikacin or cefotaxime–ampicillin) among neonates with late-onset neonatal sepsis. Methods: We conducted a retrospective cohort study comparing mortality between 2 treatment cohorts of very low birth weight neonates with late-onset sepsis, who had received amikacin–cloxacillin or cefotaxime–ampicillin between march 2014 and april 2016. 32 neonates were selected in each group after proper matching. Results: We identified a total of 150 neonates from the hospital’s record. We included 32 neonates each in the amikacin–cloxacillin and cefotaxime–ampicillin groups. Intraventricular hemorrhage, necrotizing enterocolitis, birth weight, and gestational age were significantly associated with mortality (P < 0.05). The risk of mortality was significantly higher in neonates receiving empiric cefotaxime and ampicillin than those receiving amikacin and cloxacillin .Conclusions: In our center, amikacin–cloxacillin combination therapy was associated with lower mortality in very low birth weight neonates with late-onset sepsis compared with cefotaxime–ampicillin therapy

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