AGE RELATED CHANGES IN CORPUS CALLOSUM

Kavita Nanda, Anupam Nanda, Vishal Kalia

Abstract


INTRODUCTION:- This quantitative MRI study done on 100 healthy adult individuals  between 20-60 years of age reports measurement of different dimensions of corpus callosum  and  any changes in the dimensions with ageing.

METHODS: MRI of  corpus callosum  of adult healthy individuals aged between 20-60 years were done and  morphometric measurements of different  parameters i.e. length, width, height  and  subregions of corpus callosum were noted and compared.

RESULTS: In our study it was found that-

  1.  Thickness of splenium, thickness of posterior part of corpus callosum & shortest distance from posterior most point of corpus callosum to cortical surface (P-S) increased with age.
  2. Length of corpus callosum, length of corpus callosum/length of brain increased upto 39 years and thereafter declined.
  3. Height of corpus callosum, thickness of body at mid-point, maximum thickness of the body and minimum thickness started to decrease after 50 years.

 

CONCLUSION: The results of this study indicate that ageing effects are more pronounced  in genu and anterior part of corpus callosum

Keywords


Corpus callosum, MRI, Normal Ageing

Full Text:

PDF

References


Pandya DN, Seltzer B. The topography of commissural fibres. In: Lepore F, Ptito M, Jasper HH, eds. Two Hemispheres-One Brain: Functions of corpus callosum. New York: Alan R. Liss, Inc, 1986: 47-74

Beigon A, Eberling JL, Richardson BC, Roos MS, Wong STS, Reed BR, Jagust WJ. Human Corpus Callosum in Aging and Alzhiemer’s disease: A Magnetic Resonance Imaging Study. Neurobiol Aging 1994;15: 393-397

Cowell PE, Allen LS, Zalatimo NS. A developmental study of sex and age interactions in human corpus callosum. Dev Brain Res 1992; 66: 187-92

Dreisen NR, Raz N. The influence of sex, age and handedness on corpus callosum morphology: a meta analysis. Psychobiol 1995; 23: 240-47

Johnson SC, Farnworth T, Pinkston JB, Bigler ED, Blatter DD. Corpus callosum surface area across the human adult life span: effect of age and gender. Brain Res Bull 1994; 35: 373-77

Pfefferbaum A, Lim KO, Desmond J, Sullivan EV. Thinning of corpus callosum in older alcoholic men: a magnetic resonance imaging study. Alcohol Clin Exp Res 1996; 20: 752-57

Thompson P, Narr KL, Blanton RE, Toga AW. Mapping Structural Alterations of the Corpus Callosum. During Brain Development and Degeneration. In : Zaudel E, Tacoboni M.eds. Proceedings of the NATO ASI on the corpus callosum. New York: Kluwer Academic Press 2000, in press.

Doraiswamy PM, Figiel GS, Husain MM. Aging of the human corpus callosum magnetic resonance imaging in normal volunteers. J Neuropsychiatr Clin Neurosci 1991; 3: 392-97

Weis S, Kimbacher M, Wenger E, Neuhold A. Morphometric analysis of corpus callosum using MR: Correlation of measurement with aging in healthy individuals. Amer J Neuroradiol 1993; 14: 637-45

Davatzikos C, Resnick SM. Sex differences in Anatomic measures of interhemispheric connectivity: Correlation with cognition in women but not men. Cerebral cortex 1998; 8: 635-40

Salat D, Ward A, Kaye IA, Janowsky JS. Sex differences in the corpus callosum with ageing. Neurobiology of ageing 1997; 18: 191-97

Pozzilli C, Bastimello S, Bozzao A, Pierallini A, Guibilei F, Angentino C et al. No differences in corpus callosum size by sex and aging. A quantitative study using magnetic resonance imaging. J Neuroimaging 1994; 4(4): 218-221

Sullivan EV, Pfefferbaum A, Adalsteinsson E, Swan GE, Carmelli D. Differential rates of regional brain change in callosal and ventricular size: A four year longitudinal MRI study of elderly men. Oxford University Press, 2002: 438-45

Mori S, Wakana S, Nagae PZ, Zijil V, PCM. MRI Atlas of Human White Matter. Amsterdam:Elsevier, 2005

Assaf Y, Pasternak O. Diffusion Tensor Imaging(DTI)- based white matter mapping in Brain Research: A review Journal of Molecular Neuroscience:HN.2008; 34(1): 51-61

Bowley MP, Cabral H, Rosene DL, Peters A. Age changes in Myelinated Nerve fibres of the Cingulate Bundle and Corpus Callosum in the Rhesus Monkey. The Journal of comparative Neurology. 2010; 518(15): 3046-3064

Peters A. The effects of normal aging on myelin and nerve fibres: a review. J Neurocyst.2002; 31: 581-593

Marner L, Nyengaard JR, Tang Y, Pakkenberg B. Marked loss of myelinated nerve fibres in Human Brain with age. The journal of comparative neorology.2003;462(2):144-152

Tang Y, Nyengaard JR, Pakkenberg B, Gunderson HJ. Age-induced white matter changes in the human brain: a stereological investigation. Neurobiol Aging.1997; 18(6): 609-615

Budde MD, Xie M, Cross AH, Song SK. Axial diffusivity in the primary correlate of axonal injury in the experimental autoimmune encephalomyelitis spinal cord: a quantitative pixelwise analysis. J Neurosci.2009;29(9):2805-13

Nielson K, Peters A. The effects of aging on the frequency of nerve fibres in rhesus monkey striate cortex. Neurobiol Aging.2000;21(5):621-28

Song SK, Sun SW, Ramsbottom MJ, Chang C, Russel J, Cross AH. Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage. 2002; 17(3):1429-1436.

Sun SW, Liang HF, Cross AH, Song SK. Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging. Neuroimage. 2008;40(1);1-10.

Beaulieu, C. The biological basis of diffusion anisotropy. In : Johansen-Berg, H.; Behrens, TE., editors. Diffusion MRI: From quantitative measurements to In vivo neuroanatomy. Academic Press:2012.p.106-26.

De Santis S, Drakesmith M, Bells S, Assaf Y, Jones DK. Why diffusion tensor MRI does well only some of the time: variance and covariance of white matter tissue microstructure attributes in the living human brain. Neuroimage. 2014; 89:35-44.

Kolind SH, Laule C, Vavasour IM, Li DKB, Traboulsee AL, Madler B, et al. Complementary information from multi-exponential T2 relaxation and diffusion tensor imaging reveals differences between multiple sclerosis lesions. Neuroimage. 2008; 40(1):77-85.

Madler B, Drabycz SA, Kolind SH , Whittall KP, MacKay AL. Is diffusion anisotropy an accurate monitor of myelination? Correlation of multicomponent T2 relaxation and diffusion tensor anisotropy in human brain. Magn Reson Imaging. 2008;26(7):874-888.

Sullivan EV, pfefferbaum A. A neuroradiological characterization of normal adult aging. The British Journal Of Radiology.2007; 80 (spec No 2): S99-S108

O’Sullivan M, Jones OK, Summers PE, Morris RG, Williams SCR, Markus HS. Evidence of cortical “disconnection” as a mechanism of age related cognitive decline. Neurology.2001; 57(4):632-638

Bastin ME, Maniega SM, Ferguson KJ, Brown LJ, Wardlaw JM, Mac Lullich AMJ, Clayden JD. Quantifying the effects of Normal Aging on White Matter Structures using Unsupervised Tract Shape Modelling. Neuroimage. 2010 May 15;51(1): 1-10

Elyers VV, Maudsley AA, Bronzlik P, Dellani PR, Lanfermann H, Ding XQ. Detection of normal aging effects on human brain metabolite concentrations and microstructure with whole brain MR imaging and quantitative MR imaging. Am J Neuroradiol. 2016 march; 37(3): 447-454

Bender AR, Raz Naftali. Normal-Appearing Cerebral White Matter in Healthy Adults: Mean Change over Two Years and Individual Differences in Change.Neurobiol Aging.2015 May;36(5):1834-1848


Refbacks

  • There are currently no refbacks.